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Directions for Injecting Ganirelix Acetate (Ganirelix) step by step
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Directions for Injecting Ganirelix Acetate (Ganirelix) step by step

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Everything about Ganirelix Acetate (Ganirelix)

  1. Ganirelix Acetate (Ganirelix)
  2. How do Ganirelix Acetate work?
  3. Top 3 effects of Ganirelix Acetate
  4. How should we use Ganirelix Acetate(Ganirelix) Injection?
  5. Ganirelix Acetate(Ganirelix) warning
  6. Ganirelix resource online

1. Ganirelix Acetate (Ganirelix) introduction phcoker

Ganirelix Acetate is a human-made protein which assists in the reduction of certain hormones in the body. It fits in a class of drugs known as GnRH antagonists or simply antagonists. These drugs are used to prevent premature ovulation. Today Ganirelix Acetate is very popular due to its ease of use and the high pregnancy rates it results into.

2. How does Ganirelix work? phcoker

When one is on assisted reproductive technology (ART) and is undergoing controlled ovarian hyperstimulation, she may experience a rise in the estrogen levels as a response to the Follicle Stimulating Hormone. Subsequently, it could trigger an early production of the luteinizing hormone hence premature ovulation.

As a result, the eggs released are not mature enough to provide for successful implantation or conception. That is why medical experts have come up with the GnRH antagonists, e.g., ganirelix and gonadotrophin-releasing hormone GnRH agonists, e.g., leuprolide to prevent the premature release of the luteinizing hormone hence increase the success rate of the fertility procedure.

During a controlled hyperstimulation protocol, you should inject Ganirelix Acetate around the sixth day of the FSH therapy. Ganirelix works by suppressing the luteinizing hormone production by blocking the GnRH receptors at the pituitary level. It also induces a fast and reversible suppression of gonadotrophin secretion after using it within a few days.

The suppression of the endogenous luteinizing hormone induced by Ganirelix is more than that of the endogenous follicle stimulating hormone. The administration of Ganirelix Acetate depends on the individual woman but on average; it should be used for four to five days.

Ganirelix Acetate works by controlling the production of the luteinizing hormone surge and no wonder it has been prescribed to those trying to conceive. This hormone is essential in ovulation and for the initiation of the luteal phase of the cycle. The specialist can then induce the Luteinizing hormone artificially by giving a timely injection of the human chorionic gonadotrophin (HCG). It is done once the follicles are of the appropriate size which should be evident from the ultrasound results (17mm or larger).

After the HSG administration, use of FSH and Ganirelix is discontinued. Once there is the HCG administration, the final maturation of the oocytes occurs, and ovulation happens for timed insemination methods. The oocytes could also be retrieved for ART procedures, e.g., the in vitro fertilization (IVF)


Directions for Injecting Ganirelix Acetate (Ganirelix) step by step

 

3. Top 3 effects of Ganirelix Acetate phcoker

Talking about the Ganirelix Acetate benefits, it packs them in loads. It has got everything needed to play a vital role in dealing with fertility issues. The following are some of the Ganirelix Acetate effects that result from its use;

(1) Ganirelix Acetate as Man-made protein

Ganirelix Acetate is a human-made protein that is a synthetic decapeptide. Human-made proteins have proved to be the next big thing in the world of medicine because the immune system does not target them or get degraded by enzymes, unlike natural proteins.

The human-made proteins mimic the structure and the way natural protein functions. Ganirelix Acetate works by reducing the number of certain hormones, i.e., estrogen in the body.

(2) Ganirelix Acetate helps you regulate hormones

Infertility is a bitter pill to swallow for everyone. Once you find out that you have problems when bearing a child, it may affect you emotionally. Worse still, you may feel like there is nothing you can do about it. As difficult as the situation may seem, there are medical advancements that could help you.

One of the common reasons why women cannot conceive is that they have ovulatory disorders. Fortunately, about 70% of these cases are treatable by the use of drugs. Hormonal problems are one of the main issues that cause failed ovulation. That is because the process of ovulation depends on a complex balance of hormones and for the interactions to be successful there shouldn’t be any hindrance that may stop the process.

One of the things that hinder ovulation is when the ovaries cannot produce normal follicles in which the eggs can mature. Ovulation may not happen when the eggs are immature, and the chance of fertilization happening becomes almost non-existent. 2019 Most Comprehensive Introduction To Gonadorelin Acetate

One of the Ganirelix Acetate effects is that it helps to regulate hormones during the treatment of infertility in women. During assisted reproduction, it could be used to block the action of GnRH upon the pituitary hence suppressing the production and the LH and FSH activity. Consequently, this prevents premature ovulation that could result in the harvesting of immature eggs that may not be of help especially when one is undergoing procedures like in vitro fertilization.

So if you are going through fertility problems due to ovulatory issues, then it is time that you consider using Ganirelix Acetate. With this drug, you can start your journey to proud parenting.

(3) Other effects after mixing with other drugs

Together with other medications, Ganirelix Acetate is used to treat infertility in women. Once you inject Ganirelix Acetate, the action is exerted on the pituitary gland hence inducing the production of hormones that in turn stimulate the growth and development of an egg.

In the past, Lupron was used in place of Ganirelix Acetate to block the pituitary from triggering premature ovulation. When used, it would stimulate the pituitary for a few days and then suppress it. Therefore one had to use it a few weeks before she could begin taking fertility medication for the stimulation of the ovaries.

Consequently, many women developed cysts in the ovaries, a condition that further delayed the start of using fertility medications.

One of the Ganirelix effects is that it does not have the stimulation phase; instead, the suppression of the pituitary occurs immediately. There is, therefore, no need to start the medication before starting to take fertility medication. Four to six days after you start taking your fertility medication is the best time to inject Ganirelix Acetate.  Examples of fertility medications used together with Ganirelix Acetate are Follistim and Gonal F.

Talk to your doctor about other uses regarding the use of Ganirelix Acetate injection.

4. How should we use the Ganirelix Acetate (Ganirelix) injection? phcoker

(1) Ganirelix Acetate (Ganirelix) injection?

Once you are on day two or three of the follicle-stimulating hormone (FSH) therapy, you can now start using the Ganirelix Acetate injection. 250mcg of the Ganirelix Acetate injection is administered subcutaneously once every day. Injecting Ganirelix Acetate is done during the mid to late portion of the follicular phase.

You may not require administering FSH exogenously at this moment due to the endogenous pituitary FSH secretion.

You should continue with the Ganirelix Acetate treatment until the day when you administer human Chorionic Gonadotrophin (hCG). Ultrasound may be done to assess that there is a sufficient number of follicles that are of the adequate size and it is then that hCG is administered to induce the maturation of follicles.

However, hCG should never be administered in cases whereby the ovaries have enlarged abnormally. If given on the last day of the FSH therapy it could lead to the development of OHSS (ovarian hyperstimulation syndrome)

 

Directions for Injecting Ganirelix Acetate (Ganirelix) step by step

 

(2) Injecting Ganirelix Acetate (Ganirelix) step by step

Typically, Ganirelix Acetate powder (129311-55-3) injection is provided in a sterile syringe that is usually prefilled and is only administered subcutaneously. When we talk about a subcutaneous injection, it means that the Ganirelix Acetate injection is injected under the skin.

During a subcutaneous injection, a short needle is used to inject the medication into the tissue layer located between the muscle and the skin. For the subcutaneous injection, the drug gets absorbed into the system at a slower rate and is mostly used when other methods of administration are not as effective.

Before you inject Ganirelix Acetate, check for any particles or discoloration. If you notice any of that, do not use it.

Since Ganirelix Acetate is given is a small volume, a subcutaneous injection is the best as it is the safest and most useful way to get the drug into the body. Here is how you should use Ganirelix Acetate injection step by step;

  • Look for a convenient site for the subcutaneous injection. The injection site is crucial when it comes to administering a subcutaneous injection. Ganirelix Acetate injection needs to be injected into the fatty tissue found just below the skin. Some of the areas in our bodies have a more accessible layer of tissue compared to others. These body parts are the best for such an injection because once the needle is injected, it is not likely that it will hit a bone, muscle or blood vessels. It could be on the abdomen, around the belly button or about two inches away from the navel. It could also be on the front part of the thigh.
  • Clean your hands. Wash your hands using warm water and soap to prevent yourself from suffering from any potential infection. Ensure that you thoroughly scrub the area between your fingers, under the fingernails and on the back of your hands. You could lather your hands for at least twenty seconds, wash then rinse thoroughly.
  • Gather the supplies that you are going to need. They could include the syringe containing the medication, swabs and a puncture-resistant container which you will need when you want to discard the used syringe and needles.
  • Clean and inspect the injection area. Examine the injection site to ensure that there is no swelling, bruising, hardness, burns or irritation in the area. Clean the site with a disinfectant to do away with any bacteria around the site.  Clean about two inches that area to ensure that germs do not get into the injection site. Wait for the disinfectant to dry for at least one minute before moving to the next step.
  • Hold the syringe upward and remove the needle cover.
  • Pinch a large chunk of skin between your thumb and the index finger. It helps to pull the fatty tissue away from the muscle and also make the procedure easier for you. Ensure that for every injection that you administer, you pick a different injection site. That helps to prevent damaging the area.
  • With the skin still pinched up, insert the needle at the base of that skin at an angle of 45-90% into the surface of the skin.
  • Note that when you correctly position the syringe, it will be hard to draw back on the plunger. If you notice any blood drawn into the syringe, it means that the needle tip has pierced an artery or a vein. What you should do is to withdraw the needle a little and reposition it without having to remove the needle from the skin. Also, you could consider removing the needle entirely and using a new, sterile, prefilled syringe. Take a swab that contains a disinfectant and place it on the injection site and apply some pressure. Consequently, the injection site should stop bleeding within a minute or two.
  • Repeat the step and ensure that the needle is correctly placed. You can now depress the plunger little by little gradually. That will ensure that the solution gets successfully injected while at the same time, it doesn’t leave your skin damaged. The entire amount of the drug in the syringe should be injected.
  • Remove the syringe out fast and place a swab that contains a disinfectant on the site. Do not forget to apply some pressure as it helps to counter bleeding. You may notice minor bruising once you are done, but that should not worry you. It is common and will go away even before you notice.
  • The sterile, prefilled syringe should only be used once and never shared. Once you are done, dispose of properly to avoid contamination or accidents.
  • As with any injection procedure, getting an infection is possible. If you notice any redness, swelling, severe pain or warmth, see a physician immediately.

5. Ganirelix Acetate (Ganirelix) warning phcoker

It is good that before you decide to use this drug, you get to know the Ganirelix warning. This information is critical because once you read it, you can tell whether it is safe for you to inject Ganirelix Acetate or not.

As much as you may need this drug so much, they are some conditions you could be suffering from that could make this drug potentially dangerous to you. Some may not be necessarily illnesses but lifestyle issues. Here are some of the Ganirelix warnings that could affect its effectiveness.

Ganirelix should not be used by patients who are known to suffer from hypersensitivity to this drug or any other components contained this injection. It includes patients who suffer from latex hypersensitivity since the ganirelix’s needle shield has natural rubber/latex.

Patients who have a history in Gonadotrophin-Releasing Hormone (GnRH) analogs hypersensitivity should also not inject Ganirelix Acetate. That is because doing so would lead to severe hypersensitivity reactions or anaphylaxis.

There have been cases on hypersensitivity reactions, e.g., anaphylactoid reactions that have been reported even after the first dose. No wonder women who suffer from severe allergic conditions are advised to stay away from this drug. If you are sensitive to Ganirelix Acetate or other medications like nafarelin (Synarel), goserelin (Zoladex), leuprolide (Lupron, Eligard), then you should avoid it.

 

Directions for Injecting Ganirelix Acetate (Ganirelix) step by step

 

Ovarian failure

If you have a problem with your hypothalamic-pituitary tract or ovarian response, then there is no need to inject Ganirelix Acetate powder because it might not be of any help. The reason behind this is that ovarian hyperstimulation may not help with primary ovarian failure.

Ovarian cyst, polycystic ovary syndrome

Before starting the Ganirelix treatment, you ought to know the monitoring procedures that you need to undertake. In case you notice any symptoms of ovarian enlargement, you should see a doctor immediately. They could include pelvic or abdominal pain, vomiting, nausea, ascites (distension or fluid in the abdomen) or abnormal weight gain. Guide on Ipamorelin Benefits and Ipamorelin Use

Stop using any fertility agents including that of Ganirelix if you develop ovarian hyperstimulation syndrome (OHSS) or ovarian enlargement. You may not notice maximal ovarian enlargement until you have stopped to use Ganirelix Acetate for a few days. Do not start using it again until the ovary size is back to normal.

It is recommended that before starting any fertility cycle, complete pelvic exams consisting of pelvic ultrasounds should be redone on all female patients during and before starting any fertility drug cycle. Patients who have polycystic ovary syndrome (PCOS) are overly sensitive to gonadotrophins and may exhibit an exaggerated response to ovarian hyperstimulation protocols.

Other factors that could make you suffer from ovarian hyperstimulation syndrome are high serum estradiol concentration (that is more than 400pg/ml) before the hCG administration, having a lean body and being of a younger age.

Geriatric

Research done on how Ganirelix Acetate work in the treatment of infertility in women, did not comprise a sufficient number of geriatric females. Therefore, Ganirelix Acetate is not recommended for use in older women who are looking to solve their reproductive issues.

Hepatic disease, renal impairment

Studies have not yet been done on Ganirelix effects on patients with renal impairment or hepatic disease. Anyone suffering from such a condition is urged to use this treatment with a lot of caution.

Children

Ganirelix has not yet been proved whether it is safe and effective for use on children. A Ganirelix warning is therefore given against its use in children under the age of eighteen.

Breastfeeding

Ganirelix Acetate powder causes GnRH suppression, and it is therefore not recommended for use on breastfeeding women. If a breastfeeding mother decides to use Ganirelix Acetate, then he or she should consider using alternate forms of feeding for their infant. It is not yet known whether Ganirelix could be excreted into the breast milk.

Ethanol intoxication, tobacco smoking

Drinking alcoholic beverages like beer or ethanol and tobacco smoking too could reduce fertility or the effectiveness of fertility treatments in both men and women. When one is using Ganirelix or is on any other fertility therapy, they are advised to avoid excessive use of alcohol and tobacco.

Pregnancy

It is not advisable to take Ganirelix after conception has occurred. Before starting to use Ganirelix Acetate (129311-55-3), a pregnancy test should be made to rule out its possibility.

In a study done on 283 new-borns whose mothers were administered with Ganirelix, it showed that the number of major and minor congenital anomalies were 3 and 18 neonates respectively. The major anomalies included Beckwith-Wiedemann Syndrome, omphalocele and hydrocephalus/meningocele. The minor ones included hydronephrosis, undescended testis, hydrocele, hernia inguinalis, hernia umbilical, occiput/ abnormal hand crease, torticollis/ high palate, hip subluxation, supernumerary digit finger, talipes, torticollis/ asymmetric skull, hemangioma, and sacral sinus. They could also include skin tags and nevus.

A number of the less common effects that come with the use of Ganirelix Acetate are rapid weight gain, diarrhea, bloating and abdominal or stomach pain.

The rare ones include;

  • Unusual weakness or tiredness,
  • tightness in the chest
  • skin rash, hives, itching
  • shortness of breath
  • Swelling or puffiness of the eyelids, around the face, eyes, lips, and tongue
  • Fast heartbeat
  • Dizziness
  • Difficulty while swallowing
  • Cough

6. Ganirelix source online phcoker

There are many Ganirelix sources online, but online purchase beats them all. From finding better prices to avoiding the crowds, there are many reasons why buying Ganirelix Acetate online is better than having to visit a store. Today, there are very many people buying their Ganirelix Acetate online, and I will tell you why.

With online shopping, you will not have to buy Ganirelix Acetate and carry it around. Having it in your bag all day, when you also need to carry out other personal activities could be a pain. You keep checking your pocket for the fear that it may get spilled. Sometimes you might get embarrassed when a friend you didn’t want to know that you are on medication sees it in your bag. To avoid all the worries, buy Ganirelix Acetate online and get it delivered to your doorstep.

You will enjoy the privacy that comes when you buy Ganirelix Acetate online. Nobody will ever know that you are struggling with infertility issues. You don’t have to get into a store and get that weird look once you ask for Ganirelix Acetate. On the internet, nobody will witness or judge you from the purchase that you are making. Luckily, you can buy Ganirelix Acetate online and have it delivered anonymously.

It is an entirely private matter for you to look for a way to deal with fertility issues. So next time you want to buy Ganirelix Acetate, you can buy it on the internet, and the snoopy ones will never know what you are upto.

It could cost you less amount of money as compared to walking into a store. The Ganirelix price could be lower online as compared to walk-in shops since online stores have fewer overhead costs. One more thing that should make you buy this drug online is that you will not need to make a queue in a crowded store waiting to get served. Listening to the 1980’s cover songs as you wait for tens of people before you to make their purchases could be annoying.

To avoid all this from happening, pick your laptop or phone, sit on your comfortable couch with a mug of tea and biscuit and make an order in a minute.

If you notice that you need a Ganirelix Acetate refill and do not have the time to walk from store to store looking for it, then the online purchase is the best decision you could make. You don’t have to miss a dose as your shelves will be full within the shortest time. Get it delivered as soon as you notice that you need a refill and you will never run out of it.

However, to have a smooth online buying process, you have to be very careful since it is a market like any other. On the internet, there are both legit sellers and rogue ones that will sell counterfeit drugs at deeply discounted Ganirelix cost. Others may not contain the active ingredient that you want and may therefore not deliver the Ganirelix benefits that you are after.

Other drugs may contain dangerous ingredients that are not listed, and that may have an unexpected interaction with other medications that you are on. Worse still, it could make you suffer from dangerous side effects or health problems. Other medications may not have been appropriately stored, e.g., with the necessary temperature controls and this may make the drug ineffective. As a result, you may use your money on the drug and never get to notice any Ganirelix benefits.

Phcoker.com is the best site where you can buy Ganirelix Acetate (129311-55-3). Here you get to find the best Ganirelix price and also enjoy the convenience of excellent services which will give you some peace of mind throughout the process.

We have a very dedicated customer care team that is ready to serve you as quickly and as pleasant as possible. Also, our Ganirelix price is very affordable, and you can be sure that it is friendlier than what you usually pay. We are always looking to making the Ganirelix cost lower because we care about your pocket. Also, there are no other hidden charges apart from the Ganirelix cost on the website.

Our quality is the best you will ever get in the market. You can rely on us with your health because we are a trustworthy site that will offer you with the real deal. We assure you that you will only receive pure, unadulterated Ganirelix Acetate. Once you use Ganirelix Acetate ordered from us, you will tell the difference from the one from other stores because ours delivers beyond your expectations.

We understand that good health is the backbone of living a comfortable life. With this in mind, we are the Ganirelix source that will offer you with quick deliveries, low prices, genuine Ganirelix Acetate (129311-55-3) and any other support that you may need from us.

Order from the best Ganirelix source confidently and start enjoying the Ganirelix benefits today.

 

References

  1. Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs, page 327
  2. Foye’s Principles of Medicinal Chemistry, Thomas L. Lemke, David A. Williams, page 231
  3. Mosby’s GenRx: A Comprehensive Reference for Generic and Brand Prescription Drugs, Generic Prescription Physician’s Reference Book Series, Mosby 2001, page 1133-1134

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