BPC-157 peptide: How to Inject BPC-157 or take BPC-157 orally?

1. What is BPC-157(137525-51-0)?


Peptide BPC 157, also known as Body Protection Compound-157, is a synthetic peptide made up of a chain of 15 amino acids. It is derived from a naturally occurring protein found in the gastric juice of human beings. BPC 157 is a fragment of a larger peptide called Body Protection Compound, which has been studied for its potential therapeutic effects.

Synthetic BPC 157 powder is produced through chemical synthesis in a laboratory setting. It is designed to mimic the structure and function of the naturally occurring peptide. This synthetic version of BPC 157 has been the subject of various studies to explore its potential therapeutic properties and applications.

Similar to the naturally occurring form, synthetic BPC 157 is believed to have regenerative and healing effects on the body. It has been studied for its potential to accelerate wound healing, promote tissue repair and regeneration, reduce inflammation, and support gut health. However, it is important to note that research on synthetic BPC 157 is still ongoing, and its full range of effects and mechanisms of action are not yet fully understood.

2. What does BPC-157 work on body?


Research on BPC-157 peptide has been on-going since 1991 and results thereof indicate that the peptide has the ability to repair damaged teeth, bones, muscles, tendons, and even intestines. This data is based on in-vitro lab tests as well as in-vivo studies conducted on both rodents and humans. Some of the human trials involved injecting the peptide under the skin (subcutaneously) and into the muscles (intramuscularly).

Scientists recognize BPC-157 as a “stable gastric pentadecapeptide”, due to its ability to bring equilibrium to human gastric juice. It has also been shown to treat ulcers, heal inflammatory bowel disease as well as the upper and lower GI tract with remarkable efficiency. The best part is that BPC-157 doesn’t come with any adverse side-effects!

The above mentioned studies all indicate that BPC-157 works great when it comes to fast-tracking wound healing. Through its positive interaction with the Nitric Oxide (NO) system, BPC-157 helps heal wounds by building up the blood vessels and protecting the endothelial tissue. It also promotes gene expression while specifically targeting genes that are responsible for collagen formation, generation of growth factor and cytokine. It can also heal intestinal anastomosis and short bowel syndrome. All of the above mentioned conditions are known to affect sufferers of bowel inflammation, diarrhea, constipation, and gut pain. These positive effects have been observed even in conditions that had reached advanced stages.

BPC-157 Supplements

3. What does BPC157 do for the body?

BPC 157 has been studied for its potential effects on the body, particularly in terms of promoting healing, tissue repair, and overall well-being. While research is still ongoing, here are some of the potential actions and benefits associated with BPC 157:

Accelerates wound healing

BPC 157 has been shown to promote the healing of various types of wounds, including skin wounds, muscle injuries, and tendon damage. It may enhance the formation of new blood vessels, increase collagen production, and reduce inflammation, all of which are essential for the healing process.

Supports tissue repair and regeneration

BPC 157 may have a positive impact on damaged tissues and organs. It has been studied for its potential to promote the regeneration of tissues such as bones, tendons, ligaments, and even the central nervous system.

Reduces inflammation

BPC 157 exhibits anti-inflammatory properties by modulating the production of cytokines and other inflammatory molecules. By reducing inflammation, it may help alleviate symptoms associated with various inflammatory conditions and support the healing process.

Protects and heals the gastrointestinal (GI) tract

BPC 157 has been investigated for its potential to protect and repair the gut lining, reduce inflammation in the GI tract, and improve overall gut health. It may be beneficial for conditions such as inflammatory bowel disease (IBD) and leaky gut syndrome.

Supports joint and muscle health

BPC 157 has shown potential in promoting joint and muscle health. It may help with conditions like arthritis, muscle tears, and other musculoskeletal injuries by supporting tissue repair, reducing inflammation, and enhancing recovery.

It is important to note that while BPC 157 has shown promising results in preclinical and early-stage clinical studies, further research is needed to fully understand its mechanisms of action, optimal dosages, and potential side effects. Always consult with a qualified healthcare professional before using BPC 157 or any other peptide or experimental compound.

4. Does BPC 157 really work?

Most of the research we have on BPC157 right now has been conducted on animals or isolated cells. Despite these, anecdotal evidence is overwhelmingly positive and supplementing with BPC157 following injuries or surgeries is becoming increasingly more popular, especially in those who want a fast return to training such as powerlifters and bodybuilders. With a long list of benefits of BPC-157 supplementation and usually only a fairly low cost, it is certainly something to consider when other supplements and therapies have failed.

5. Peptide BPC-157 for Bodybuilding

BPC-157 has gained attention among some individuals involved in bodybuilding and athletic performance for its potential benefits in promoting recovery, injury healing, and tissue repair. While research on BPC-157’s effects in bodybuilding is limited and ongoing, here are some potential ways it may be relevant:

Injury recovery

Bodybuilding often involves intense workouts that can lead to muscle strains, tears, or other injuries. BPC-157 may promote the healing and repair of these injuries by accelerating the regeneration of muscle tissue, tendons, and ligaments. This may potentially shorten recovery time and allow athletes to get back to their training sooner.

Joint and tendon health

BPC-157 has shown promise in promoting the healing of damaged tendons and improving joint health. This may be beneficial for bodybuilders who put significant stress on their joints and tendons through heavy lifting and intense training.

It is crucial to note that BPC-157 is still an experimental compound, and its use for bodybuilding purposes should be approached with caution. Additionally, it is essential to remember that only buy high quality and potency BPC 157 peptide through a regular manufacturer. If you are interested in buying BPC 157 online, look no further than Phcoker. We’re a proud manufacturer of top-quality peptides, nootropics and supplements of all types. We only sell pharmaceutical grade BPC-157 manufactured in our factory; All peptides undergoes strict testing protocols before being available.

6. Shared experiences after use BPC-157

I originally use BPC-157 for my biliary system and leaky gut, but found it to have other systemic effects. I’ve only taken it orally and sublingually and it has helped me with my sleep, cognition, and food intolerances. I only need very little doses (~50mcg). I’ve also noticed increase histamine in my gut from it (could be part of the repair process). I will be trying it soon for my blood-brain barrier issues with CIRS (intranasally or injected).

Some people I know have taken it intranasally or corneally (as eye drops) and it has worked. Others have reported it significantly helping their workouts, spinal injuries, anhedonia, depression, IBS, anxiety, and Post Orgasmic Illness Syndrome (to name a few).

Here’s my speculation and what I hope to see research in: I would love to know how BPC-157 works on tight junctions in the gut and zonulin-1 (ZO-1) or it’s effect on the microbiome/microbial byproducts and peptides as it seems to reverse a lot of dysbiosis-related disorders.

7. How to use BPC-157?

BPC-157 can be administered in two primary ways: through injections or orally, each offering distinct advantages and considerations.

For individuals who prefer a needle-free approach or have aversions to injections, BPC-157 orally provide an alternative. However, it is important to note that when taken orally, not all of the BPC-157 dosage may be fully absorbed due to digestion and metabolism processes.

On the other hand, injecting BPC-157 offers a more efficient and faster-acting method. This method is often favored by professional athletes who seek direct benefits for specific injured areas by delivering the peptide directly into the bloodstream and muscles. It is worth mentioning that both injection and oral administration of BPC-157 can provide systemic effects throughout the body, not solely confined to the targeted area.

(1) BPC-157 Injection

There are two types of injecting methods: intramuscular and subcutaneous. Intramuscular injection is applied near the muscle which is pain. By injecting it deeply inside the muscle you will be able to provide BPC-157 to your body for healing. The other method is subcutaneous injection which is applied under the skin. Both of them are useful injecting methods.

How to get the BPC-157 online?

You can buy BPC-157 at a few different peptide suppliers on the internet. You can pretty easily find it and buy BPC-157 if you know how to use your Googling skills properly.

You’ll notice each site specifies that it is for laboratory chemical research only. It is important to buy BPC-157 from a reputable supplier,so that the quality of the peptide BPC-157 can be ensured.Professional BPC-157 manufacturer and supplier Phcoker can supply BPC-157 with high quality for the support of the independent R&D center and factory.If you have needs,BPC-157 wholesale from Phcoker is a great choice.

What do you need to do before inject BPC-157?

① One box of insulin syringes, preferably 1ml/1cc, with 28 gauge 1/2 inch attached needles (the slang term for these syringes), among self-injectors of peptides and hormones, is a “slin pin”.

② One 30ml bottle of bacteriostatic water.

③ One package of alcohol cleaning wipes.

How to mix BPC-157?

① Pop the caps off both the BPC-157 and bacteriostatic water.

② Gently alcohol swab the rubber stopper on the BPC-157, then let it dry. Same goes with the bacteriostatic water vial.

③ Dose out the correct amount of bacteriostatic water. In the case of a 30ml bottle of bacteriostatic water, if you fill three insulin syringes full of water, then very slowly and carefully (peptides are extremely fragile) inject each of those syringes into a 5mg bottle of BPC-157, you are going to nearly completely fill the 5mg bottle of BPC-157.

④ Once the 5mg bottle of BPC-157 is full, then based on this very handy Peptide Mixing & Dosing Calculator, each time you inject a 1ml/1cc syringe into it and pull that syringe back to the fifteenth tick mark, you are going to have yourself approximately 250mcg of BPC-157.

How to store B-157 after mix?

Before and after reconstitution, keep your BPC-157 away from UV rays, sunlight and heat. It will remain stable at room temperature for up to ten weeks, but for best storage and results, you should store in your refrigerator, in which case it will stay stable for up to six months. It will stay stable in a freezer for up to two years.

The stuff is super fragile. I cannot emphasize enough the importance of very slow and patient reconstitution. When you spray the bacteriostatic water into the BPC-157, aim for the sides of the BPC157 bottle, and don’t spray directly onto the BPC-157 powder itself. When you draw the BPC157 up into the syringe for injection or oral use, turn the bottle of BPC-157 upside down very carefully and then draw the liquid up into the syringe very slowly. When you inject it or spray it into your mouth, inject it very slowly. If you keep it in the refrigerator, keep it away from things that might knock it over or jostle it around.

How to inject BPC-157?

♦ Subcutaneous injection

The subcutaneous method is the easiest and least painful because it involves inserting the injection under the skin, preferably in an area as close to the injury or pain-point as possible.

♦ Intramuscular injection

Alternatively, you can inject BPC-157 intramuscularly, which means stabbing the needle right into the muscle. Needless to say, this is a very painful method, especially when you consider that it’s typically done in an area that’s close to the injury as well.

 Spray BPC-157 into your mouth

By far the easiest method is to spray the peptide into your mouth. Just make sure to hold the liquid inside your mouth for about 90 to 120 seconds before swallowing.

If you’re okay with needles then you can always opt for a subcutaneous needle instead. All you have to do is pinch an area of the skin as close as possible to the injury, making sure to angle the needle so that it sort of “slips” underneath the area of the skin that you’ve pinched and not directly onto it. This can be a bit difficult to do so it might be a good idea to get someone to help you out with it. Remember to use an alcohol swab to clean the area of the skin that you’re about to inject, as well as the rubber stopper before and after the injection.

The most painful yet equally effective method that you can choose is the intramuscular injection. Similar to subcutaneous injections, this method requires that you clean the rubber stopper and the part of the skin that you’re about to inject with an alcohol swab. However, you’ll be stabbing the skin with the needle instead of working it in like you would with the subcutaneous method. Keep in mind that you’ll be administering the needle as close to the affected area as possible, which might add to the pain. But, thinking happy thoughts have been shown to help in some instances although we can’t guarantee the efficacy of that method. On the bright side, this method will enable the peptide to work quickly and accelerate healing.

BPC-157 Supplements How to Inject BPC-157or take BPC-157 zpsew4
BPC-157 Supplements:How to Inject BPC-157 or take BPC-157 orally?

(2) Oral BPC-157 

When it comes to taking it orally, you simply have to spray the compound in your mouth through the syringe. This method should be performed with proper care to avoid any mouth injuries.

Oral BPC-157: The effective BPC-157 dosage

If you choose to take BPC-157 orally, determining the optimal dosage can be challenging due to the limited research available. Anecdotal reports and user experiences vary widely, and there is no consensus on the ideal oral dosage.

8. BPC-157 vs. TB-500 (Thymosin Beta-4)?

BPC-157 and TB-500 are both synthetic peptides that have gained attention for their potential therapeutic applications, particularly in the field of tissue repair and healing. Researchers interested in working with BPC-157 may be curious about how it compares against TB-500. While they share some similarities, there are also notable differences between the two peptides. Here’s a comparison:

Structure and source: BPC-157 is a synthetic peptide derived from a protein found in the gastric juice, while TB-500 is a synthetic version of Thymosin Beta-4, a naturally occurring peptide derived from the thymus gland.

Mechanisms of action: BPC-157 is believed to promote tissue repair, healing, and angiogenesis (formation of new blood vessels). It also has anti-inflammatory effects. TB-500, or Thymosin Beta-4, is known for its role in promoting wound healing, tissue regeneration, and cell migration. It may also modulate immune responses and have anti-inflammatory effects.

Targeted applications: BPC-157 has been studied for a wide range of conditions, including musculoskeletal injuries, gastrointestinal disorders, and neurological conditions. It is known for its potential to accelerate the healing of various tissues, such as muscles, tendons, and skin. TB-500 is primarily studied for its wound healing properties, especially in skin injuries, corneal injuries, and cardiac tissue repair. It may also have potential in treating muscle injuries and promoting muscle recovery.

Administration: Both BPC-157 and TB-500 can be administered through subcutaneous or intramuscular injections. Oral administration of BPC-157 has also been explored, although the effectiveness of this method is still debated.

9. Frequently Asked Questions

Is BPC-157 legal?

Technically, no. BPC-157 is not legal or compliant with the FDA for use in humans. However, it is legal to purchase BPC-157 for sale if it is for research purposes only.

Is BPC 157 a steroid?

BPC-157 is not a steroid. It is a peptide, or chain of amino acids. It does not have the anabolic or androgenic effects of AAS. Instead, it may assist athletes by assisting the repair and regeneration of muscles and connective tissues among other benefits.

Does BPC 157 build muscle?

BPC does not directly build muscle, however in bodybuilders looking to optimize recovery between sessions and stay injury-free, it can increase how frequently you can train to a high intensity without having to take a step back.

Can you take BPC 157 orally?

You can indeed take BPC-157 orally with capsule supplements such as Unbreakable by Hydrazine utilizing orally-active BPC. A higher dose may be needed to achieve the same results but this is preferable to many and avoids risks associated with self-injecting.

What’s the Best Time of Day to Take BPC-157?

BPC-157 injections should always be done on an empty stomach at the same time of day. We recommend taking your first dose in the morning or early afternoon. If more than one dose is needed daily, spread them by at least three hours.

How long does BPC 157 take to work?

You might see results from BPC-157 in as little as 24-48 hours, depending on the severity of the injury it is being used to treat. If you do not immediately see the results you want, we’d suggest waiting a week or two before thinking about adjusting dosage.

Does BPC 157 raise blood pressure?

In rats, BPC 157 actually stabilized blood sugar. Only when combined with l-arginine did it increase blood pressure. We do not currently have enough evidence to confidently say whether this would be replicated in human subjects.

Is BPC 157 systemic?

BPC does not need to be injected at the point of injury (for example, if the pain is coming from the achilles tendon). This is why whether you inject subcutaneously, intramuscularly, take BPC capsules orally or use a spray it is effective. This is one of the reasons that makes peptide therapy so appealing to athletes.

What are some risks and side effects of using BPC-157

While BPC-157 has shown promise in promoting gut health, there are potential risks and side effects to consider. There is a lack of long-term safety data, as well as the potential for allergic reactions. It is important to only use regulated and high-quality BPC-157 products and to follow recommended dosages and administration methods.

What is the proper dosage for BPC-157

The recommended dosage of BPC-157 varies depending on the severity of gut issues and body weight. Before starting BPC-157, it’s important to talk to a licensed practitioner to figure out the right dose.

How is BPC-157 Administered?

BPC-157 can be administered through injection or oral consumption. Each method has its pros and cons, and the effectiveness of each method may vary depending on the individual.

Author of this article:

Dr. Stans Bastiras graduated from University of California, San Diego
Scientific Journal paper Author:

1.Y. Tohyama

Cone Neurosurgical Research Laboratory, Department of Neurology and Neurosurgery, and Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4

2.Martina Lovric-Bencic

Department of Pharmacology, Medical Faculty, University of Zagreb, Zagreb, Croatia

3.Predrag Sikirić

Center for Digestive Diseases, Medical Faculty, Medical and Veterinary Faculty, University of Zagreb, P.O. Box 916, Šalata 11, 10000 Zagreb, Croatia

4.P. Sikirić

Department of Pharmacology, Medical Faculty, University of Zagreb, Zagreb, Croatia

In no way do these doctors or scientists endorse or advocate the purchase, sale, or use of this product for any reason. Phcoker has no affiliation or relationship, implied or otherwise, with these physicians. The purpose of citing them is to acknowledge and commend the exhaustive research and development work done by the scientists working on this substance.


[1]Kang EA, Han YM, An JM, Park YJ, Sikiric P, Kim DH, Kwon KA, Kim YJ, Yang D, Tchah H, Hahm KB.”BPC157 as Potential Agent Rescuing from Cancer Cachexia.”Curr Pharm Des. 2018;24(18):1947-1956. doi:10.2174/1381612824666180614082950.PMID: 29898649

[2]Lee E, Padgett B. “Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain.”Altern Ther Health Med. 2021 Jul;27(4):8-13.PMID: 34324435

[3]Tohyama Y, Sikirić P, Diksic M.”Effects of pentadecapeptide BPC157 on regional serotonin synthesis in the rat brain: alpha-methyl-L-tryptophan autoradiographic measurements.”Life Sci. 2004 Dec 3;76(3):345-57. doi: 10.1016/j.lfs.2004.08.010.PMID: 15531385

[4]Xu C, Sun L, Ren F, Huang P, Tian Z, Cui J, Zhang W, Wang S, Zhang K, He L, Zhang W, Zhang C, Hao Q, Zhang Y, Li M, Li W.”Preclinical safety evaluation of body protective compound-157, a potential drug for treating various wounds.”Regul Toxicol Pharmacol. 2020 Jul;114:104665. doi: 10.1016/j.yrtph.2020.104665. Epub 2020 Apr 22.PMID: 32334036

[5]He L, Feng D, Guo H, Zhou Y, Li Z, Zhang K, Zhang W, Wang S, Wang Z, Hao Q, Zhang C, Gao Y, Gu J, Zhang Y, Li W, Li M.”Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157, a potential drug for treating various wounds, in rats and dogs.”Front Pharmacol. 2022 Dec 14;13:1026182. doi: 10.3389/fphar.2022.1026182. eCollection 2022.PMID: 36588717

[6]Hsieh MJ, Liu HT, Wang CN, Huang HY, Lin Y, Ko YS, Wang JS, Chang VH, Pang JS.”Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation.”J Mol Med (Berl). 2017 Mar;95(3):323-333. doi: 10.1007/s00109-016-1488-y. Epub 2016 Nov 15.PMID: 27847966

[7]Wang XY, Qu M, Duan R, Shi D, Jin L, Gao J, Wood JD, Li J, Wang GD.”Cytoprotective Mechanism of the Novel Gastric Peptide BPC157 in Gastrointestinal Tract and Cultured Enteric Neurons and Glial Cells.”Neurosci Bull. 2019 Feb;35(1):167-170. doi: 10.1007/s12264-018-0269-8. Epub 2018 Aug 17.PMID: 30116973

[8]Lovric-Bencic M, Sikiric P, Hanzevacki JS, Seiwerth S, Rogic D, Kusec V, Aralica G, Konjevoda P, Batelja L, Blagaic AB.”Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse.”J Pharmacol Sci. 2004 May;95(1):19-26. doi: 10.1254/jphs.95.19.PMID: 15153646

[9]Sikirić P, Seiwerth S, Grabarević Z, Rucman R, Petek M, Jagić V, Turković B, Rotkvić I, Mise S, Zoricić I, Konjevoda P, Perović D, Jurina L, Separović J, Hanzevacki M, Artuković B, Bratulić M, Tisljar M, Gjurasin M, Miklić P, Stancić-Rokotov D, Slobodnjak Z, Jelovac N, Marović A.”The influence of a novel pentadecapeptide, BPC 157, on N(G)-nitro-L-arginine methylester and L-arginine effects on stomach mucosa integrity and blood pressure.”Eur J Pharmacol. 1997 Jul 30;332(1):23-33. doi: 10.1016/s0014-2999(97)01033-9.PMID: 9298922

[10]Boban-Blagaic A, Blagaic V, Romic Z, Jelovac N, Dodig G, Rucman R, Petek M, Turkovic B, Seiwerth S, Sikiric P.”The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice. The effect of N(G)-nitro-L-arginine methyl ester and L-arginine.”Med Sci Monit. 2006 Jan;12(1):BR36-45. Epub 2005 Dec 19.PMID: 16369461

[11]Sikirić P, Seiwerth S, Desković S, Grabarević Z, Marović A, Rucman R, Petek M, Konjevoda P, Jadrijević S, Sosa T, Perović D, Aralica G, Turković B.”New model of cytoprotection/adaptive cytoprotection in rats: endogenous small irritants, antiulcer agents and indomethacin.”Eur J Pharmacol. 1999 Jan 1;364(1):23-31. doi: 10.1016/s0014-2999(98)00818-8.PMID: 9920181

[12]Jung YH, Kim H, Kim H, Kim E, Baik J, Kang H.”The anti-nociceptive effect of BPC-157 on the incisional pain model in rats.”J Dent Anesth Pain Med. 2022 Apr;22(2):97-105. doi: 10.17245/jdapm.2022.22.2.97. Epub 2022 Mar 25.PMID: 35449779

[13]Škrlec K, Ručman R, Jarc E, Sikirić P, Švajger U, Petan T, Perišić Nanut M, Štrukelj B, Berlec A.”Engineering recombinant Lactococcus lactis as a delivery vehicle for BPC-157 peptide with antioxidant activities.”Appl Microbiol Biotechnol. 2018 Dec;102(23):10103-10117. doi: 10.1007/s00253-018-9333-6. Epub 2018 Sep 6.PMID: 30191288

[14]Huang T, Zhang K, Sun L, Xue X, Zhang C, Shu Z, Mu N, Gu J, Zhang W, Wang Y, Zhang Y, Zhang W.”Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro.”Drug Des Devel Ther. 2015 Apr 30;9:2485-99. doi: 10.2147/DDDT.S82030. eCollection 2015.PMID: 25995620

[15]Sikiric P, Seiwerth S, Mise S, Staresinic M, Bedekovic V, Zarkovic N, Borovic S, Gjurasin M, Boban-Blagaic A, Batelja L, Rucman R, Anic T.”Corticosteroid-impairment of healing and gastric pentadecapeptide BPC-157 creams in burned mice.”Burns. 2003 Jun;29(4):323-34. doi: 10.1016/s0305-4179(03)00004-4.PMID: 12781609