What Is Dihydromyricetin (DHM)?

Dihydromyricetin (DHM) is making rounds as a recognizable supplement in aiding morning recovery. It’s nothing new as it has been widely used in Korea, China, and China since the year 659 for a hangover cure. Interestingly, it has only come into the limelight around 2012 after more research was done on it.

Also known as the Oriental Raisin tree or the Japanese Raisin tree, DHM (27200-12-0) is a herbal compound found in Hovenia Dulcis. It is also commonly found in Ampelopsis Glossendentata, also referred to as the Rattan tea. Being a deciduous tree, it could grow as high as 1.2meters and bear berry-like fruits whose taste is similar to that of raisins.

How Was Dihydromyricetin (DHM) Discovered?

Dihydromyricetin became known when Jing Liang, an associate professor from UCLA, school of medicine, researched it. The study involved mice, and this helped prove that there was some science in it. They were administered with alcohol and DHM and the same compared to the placebo.

The first test that Jing and her team did was to ascertain whether DHM blocks the effect of alcohol on the GABA and the brain’s Glutamate neurotransmitters. The researchers were, therefore, keen to observe any changes in the cognitive skills, loss of coordination, and clumsiness.

The studies showed that DHM prevents intoxication and withdrawal symptoms. It also accelerates the rate in which alcohol is broken down.

 

How Does Dihydromyricetin Work In Your Body?

Let’s first start by understanding what alcohol does to the brain. It causes an imbalance between two types of neurotransmitters; Glutamate and Gamma-Aminobutyric Acid (GABA). The two chemicals are responsible for controlling feelings, thoughts, and coordination.

When alcohol gets into the body, it binds to the GABA receptors, activates them, leading to slurred speech, relaxation, and impaired motor function. This action makes the brain believe that there could be an imbalance. To restore this, less GABA is produced by the body. When alcohol is metabolized and excreted, less GABA is left in the brain. That’s when agitation, anxiety, poor sleep quality, and headache start kicking in.

DHM impacts the way alcohol is processed in the brain through the GABA receptors. It binds to them; hence less alcohol binds to it.

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What Benefits Can We Get From Dihydromyricetin (DHM)?

Have you suffered from the dreaded hangover after indulging? If you have woken up after having an epic night feeling like death, then you will appreciate how Dihydromyricetin works to defeat the bad feeling. It has proven to reduce and prevent symptoms brought about by alcohol consumption. That means that no matter how much you decide to take, you will be feeling pretty good.

This remedy has proven not only to be useful, but it is safe too. While most of the compounds with the same benefits have left some fighting for their lives due to severe side effects, DHM will rarely affect you negatively. Here are some of the Dihydromyricetin benefits;

 

😉 Keeps hangover at bay

The best way to prevent a hangover is by taking Dihydromyricetin. That is because it is the only supplement that attacks three out of the four primary causes of hangovers. They are;

 

😐 Sleep deprivation

If you are used to drinking or have even done it occasionally, you might have suffered from sleep problems. Once you take alcohol, you notice that sleep comes fast, but once the alcohol levels in your body reduce, your sleep goes. That is because of changes in the GABA level in the body. It is an inhibitory neurotransmitter that slows brain activity and makes one fall asleep more easily.

Once you take alcohol, there is more GABA in your brain. No wonder the sound sleep. When the alcohol starts to leave your body, your body produces GABA. That is in a bid to compensate that which was being produced by alcohol. Unfortunately, the body cannot provide the same amount of GABA as that produced by alcohol. That means that if the alcohol fully leaves your body in the middle of the night, there will be much less GABA present hence leading to awakening and undergoing difficulty falling back asleep.

You need to note that sleep deprivation is not a significant cause of the hangover symptoms but contributes to it by adding on the fatigue. By reducing the withdrawal effect on GABA, Dihydromyricetin works to maintain the GABA levels hence allowing you to enjoy some quality sleep even after a night out. That makes you feel less fatigued.

 

😀 Short term alcohol withdrawal

Anyone who has tried to quit alcohol will tell you how it could bring you horrible withdrawal symptoms. Not only does this occur when you stop drinking, but it could also happen to some after a night of drinking. While drinking, your brain is usually compensating for the presence of alcohol. The next morning when the alcohol level in the body is almost zero, there is a short term withdrawal as a result of having less GABA in the brain.

The use of Dihydromyricetin helps in reducing the ability of alcohol molecules to bind to the brain’s GABA receptors. When there is less alcohol binding with the receptors, then the brain will not have to compensate much. Consequently, you are less likely to suffer from hangover symptoms.

 

 😳 Dehydration

Although dehydration is not the sole cause of hangovers, it is known to contribute to it. Dihydromyricetin (DHM) comes in handy is replenishing your body with electrolytes so that you do not have to keep feeling miserable due to the throbbing headache or nausea.

That is because electrolytes work like conductors in the body. They play a significant role in most of the cell functions, including tissue repair, fluid regulation, and energy creation. The most important one, in our case, is helping the body in allocating the fluids to the cells where they are most needed.

 

😐 Acetaldehyde toxicity

Alcohol breakdown in the liver involves several steps. First, it is broken down into smaller molecules that are then metabolized out of the bloodstream. Acetaldehyde is one of the byproducts in this process.

Acetaldehyde is a toxic molecule whose buildup could lead to the damage of body organs. Even worse, it is carcinogenic. Usually, it is known to cause most of the hangover symptoms, including headaches, nausea, and a general feeling of illness.

Acetaldehyde works to reduce hangover by improving the way liver enzymes work. It promotes the process in which acetaldehyde dehydrogenase and alcohol dehydrogenase breaks down acetaldehyde and alcohol, respectively. That means that taking DHM will help in a faster breakdown of alcohol and acetaldehyde hence mitigating the risk of suffering from a hangover.

 😉 Reduces alcohol intoxication

Typically, upon taking alcohol, you need some time to rest and sober up. Depending on how much one has consumed, it could take several hours before it all gets metabolized. Other than spending hours in bed to beat existing alcohol intoxication, you could opt to use Dihydromyricetin. It does this in two ways;

 

😛 It improves the ability of the liver to metabolize alcohol.

For every alcoholic drink one has, it takes roughly one hour for it to be metabolized. That means that if you took a beer now, you might only feel completely sober after an hour. By then, it will all have been broken down.

By taking Dihydromyricetin, alcohol is cleared from the body at a faster rate. By increasing the rate in which alcohol dehydrogenase breaks down alcohol molecules, Dihydomyricetin clears alcohol from the bloodstream faster than it could.

 

😎 It blocks alcohol from affecting the brain

The presence of alcohol in the brain affects it by binding with GABA receptors. Consequently, this makes the body act as if there is more neurotransmitter GABA like it usually is. GABA is an inhibitory neurotransmitter, and when there is much of it in the body, it leads to one feeling more drunk and relaxed. That is due to the lowered inhibitions.

Fortunately, one of the Dihydromyricetin benefits is that it prevents some alcohol molecules from binding with the GABA receptors.  Thus, you will feel less drunk since the effect of alcohol on your brain is reduced. Often this will happen even when your BAC levels are high

 

 😀 Dihydromyricetin prevents alcohol intoxication

Prevention is always better than dealing with something that already happened. Ideally, taking DHM before involving yourself with alcohol could save you intoxication. That means that it is possible to enjoy a few drinks without having to affect your brain and health too. You are wondering how this happens? DHM improves the way your liver processes alcohol and by blocking its effects in your brain. Taking DHM will guarantee you enough protection against intoxication as a result of alcohol intoxication.

Another way that DHM helps in the prevention of alcohol intoxication is that it reduces the amount of alcohol that will be absorbed in the GI tract. It has been shown to effectively reduce the intoxication once taken before drinking as less alcohol will be absorbed into the bloodstream.

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How Can We Use DHM in Our Life?

 

A: Best time to use Dihydromyricetin (DHM)

If you are the type of person who will want to enjoy a few beers and still make it to work in the morning, then you ought to know how to use Dihydromyricetin. To enjoy the Dihydromyricetin benefits, you have to take it before going to bed after a night of drinking or once you have had your last drink. By doing this, you allow DHM to work while you are asleep and clear the alcohol in the body before it starts causing any adverse effects.

You remember that once you take alcohol, acetaldehyde will be in plenty, so it is best to use Dihydromyricetin so that it mops it out. You could also incorporate other things before indulging just to ensure that your body is in check. Well, with a stomach full of alcohol and a liver under stress, having a good meal and staying hydrated all through could help a lot.

The main point here is that Dihydromyricetin may not be of much help once taken when the hangover has kicked in. Instead of having to keep up with the hangover until your body recovers hours later, you can always remind yourself to take DHM after your last pop.

 

B: Recommended dosage on DHM

Although the recommended Dihydromyricetin dosage is 300mg, higher doses may be effective and safe too. A study done on mice proved that DHM could be tolerated even at 3500mg. Sounds high, right? What’s important is to know what works for you. You could start at a low Dihydromyricetin dosage and go high as you watch your body. Anything between 100-1000mg isn’t that bad.

It is, however, important to mention that DHM is poorly absorbed into the bloodstream. Other factors, like acidity, could even make it worse. That means that once ingested, only a fraction of it does what it is supposed to.

 

C: Usages cautions for DHM (side effects included)

Like drugs, one would expect that DHM will have some side effects. Luckily, it has proven to be safe for all the benefits it offers. It is non-toxic and presents no side effects even at high doses.

In the past, Hovenia Dulcis’ tree extracts have been used in Korea and China in the prevention of hangovers.  So the lack of any side effects doesn’t come as a surprise. Also, studies have been done and yielded the same results. One study done showed that DHM was the only supplement that treats alcohol use disorders without causing any significant side effects. Another study done on mice proved that it is entirely non-toxic at a high dose of 22g/kg of body weight.

That said, DHM could become unsafe if you use it as an excuse to indulge more. You shouldn’t take more than you usually do. That is because it leads to irresponsible drinking behaviors. It would even put you at a higher risk if you decided to drink and drive.

If you are on any kind of medication, it would be safe for you to discuss with your doctor on DHM usage. He/she will help determine if you should take it and ascertain the right DHM dosage for you.

 

Dihydromyricetin (DHM) Sources

 

DHM Capsules VS DHM Powder

One question that you many people tend to ask is which the best DHM form to take is. There are the powder and the capsules, and this allows you to choose what suits you best. There may be a difference in their convenience, stability, and absorption. However, in terms of effectiveness, both give good results. If you are not able to pick the one that works best for you, here is a checklist that you could use;

 

Capsules

If you are going to enjoy your beer or wine in a bar or at a friend’s place, you will want to carry the DHM with you. That’s precisely one of the advantages that capsules offer. They are portable, and you can just sneak them in your pockets so that not everyone has to see them. No need to pack a whole container of DHM during your night outs.

Also, you won’t have to worry that powder will spill over. You know when you start getting tipsy, you may be a little clumsy, and getting untidy might be one of your fears. Well, capsules save you from all that as they will rarely spillover.

The other benefit is that capsules are easier to take. You only have to do is grab them and take them. There is so much convenience in this since you do not need to keep getting a spoon scooping, measuring, and mixing your stuff.  You could have your capsule in the oddest of places.

However, it could take some time for the capsules to release the contents and to have them dissolved.

 

Powder

The powder form will be your weapon of choice if you have issues swallowing. You only need to get water, juice, or milk and mix your thing. It also gives almost instant results as it starts getting absorbed the moment it gets to your stomach. Who wouldn’t want quicker results?

It might a task taking the powder when you are out having fun with friends. You could, however, wait and take it once you get home just before retiring to bed.

 

Best place to buy Dihydromyricetin (DHM) Online

Are you feeling sick or sluggish after taking alcohol? You might just need DHM to prevent all that next time you decide to let yourself loose. So, where do you buy Dihydromyricetin? How do you know that you have spotted the right Dihydymyricetin powder supplier? If you buy Dihydromyricetin from anybody, you may end up not getting the real product. That’s why we are here.

We are genuine Dihydomyricetin powder suppliers who offer quality at an affordable price. Want to beat all hangover associated symptoms? We are a click away!

 

References
  1. Chen SH, Zhong GS, Li AL, Li SH, Wu LK. Influence of Hovenia dulcis on alcohol concentration in blood and activity of alcohol dehydrogenase (ADH) of animals after drinking. Zhongguo Zhong Yao Za Zhi. 2006;31:1094–1096.
  2. Yi Shen, A. Kerstin Lindemeyer, Claudia Gonzalez, Xuesi M. Shao, Igor Spigelman, Richard W. Olsen & Jing Liang (2012). “Dihydromyricetin as a novel anti-alcohol intoxication medication”. The Journal of Neuroscience. 32 (1): 390–401.
  3. Chen, Shihui; Zhao, Xiaolan; Wan, Jing; Ran, Li; Qin, Yu; Wang, Xiaofang; Gao, Yanxiang; Shu, Furong; Zhang, Yong; Liu, Peng; Zhang, Qianyong; Zhu, Jundong; Mi, Mantian (2015). “Dihydromyricetin improves glucose and lipid metabolism and exerts anti-inflammatory effects in nonalcoholic fatty liver disease: A randomized controlled trial”. Pharmacological Research. 99: 74–81.
  4. Li, Hongliang; Li, Qisheng; Liu, Zhaowen; Yang, Kai; Chen, Zhixi; Cheng, Qilai; Wu, Longhuo (2017). “The Versatile Effects of Dihydromyricetin in Health”. Evidence-based Complementary and Alternative Medicine : ECAM. 2017: 1053617.

 

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