Cycloastragenol (CAG) also known as T-65 is a natural tetracyclic triterpenoid obtained from the Astragalus membranaceus plant. It was first discovered when Astragalus membranaceus extract was being evaluated for its active ingredients with anti-aging properties.
Cycloastragenol can also be derived from Astragaloside IV via hydrolysis action. Astragaloside IV is the major active ingredient in Astragalus membranaceus herb. Although Cycloastragenol and Astragaloside IV are similar in their chemical structure, cycloastragenol is lighter in molecular weight than Astragaloside IV. Consequently, Cycloastragenol is more efficient due to high bioavailability and thus high metabolism of cycloastragenol. The high metabolism of cycloastragenol is noted in the intestinal epithelial via passive diffusion.
The astragalus herb have been used as a Chinese traditional medicine for centuries and is also being used today. Astragalus plant has been used due to its beneficial effects including anti-bacterial, anti-inflammatory as well as ability to enhance immunity.
CAG is indicated as an anti-aging compound that boosts the activity of the enzyme telomerase and wound healing. It is currently the major compound known to induce telomerase in humans, thus a great prospect supplement for further development.
Cycloastragenol is identified as telomerase activator, that plays role of increasing the length of telomeres. Telomeres are protective caps composed of nucleotide repeats at the end of the chromosome. These telomeres become shorter after every cell division which results to cell senescence and degradation. Further, the telomeres could also be shortened by oxidative stress.
This extreme shortening of telomeres is associated with aging, death and some ag-related disorders. Fortunately, telomerase enzyme is able to increase the length of these telomeres.
Although there no extensive studies to prove the ability of cycloastragenol to extend lifespan, it is a promising anti-aging compound. It has been proved to eliminate the signs of aging including fine lines and wrinkles. CAG may also lower the threat of developing degenerative disorders such as Parkinson’s, Alzheimer’s, and cataracts.
Despite the many cycloastragenol health benefits, there are concerns that it could lead to cancer or accelerate cancer. However, some studies conducted with animal subjects report benefits of cycloastragenol without any incidence of cancer.
Cycloastragenol powder for sale is readily available online and can be purchased from the many well-known cycloastragenol suppliers.
Despite, the many cycloastragenol health benefits indicated, it is still a new member under studies. Furthermore, cycloastragenol side effects are not very clear, hence should be used with caution.
What is Cycloastragenol?
Cycloastragenol is a triterpenoid saponin compound derived from the root of Astragalus herb. Astragalus membranaceus plant has been used in Traditional Chinese medicine (TCM) for over 2000 years and still being used in herbal preparations.
The astragalus herb has been known for its ability to improve the immunity, protect the live, act as a diuretic as well as a possess other health properties such as anti-hypersensitivity, antibacterial, anti-aging and anti-stress benefits.
Cycloastragenol commonly known as TA-65 but has also been referred to as Cyclogalagenin, Cyclogalegenin, Cyclogalegigenin, and Astramembrangenin. Cycloastragenol supplement is largely known as anti-aging agent, however, other cycloastragenol health benefits include enhancing immune system, anti-inflammatory and anti-oxidative properties.
Cycloastragenol and Astragaloside IV
Both cycloastragenol and Astragaloside IV occur naturally in the astragalus plant extract. Astragaloside IV is the primary active ingredient in astragalus membranaceus, however, occurs in minute quantities in the root. The process of extracting these saponins, cycloastragenol and astragaloside IV, is usually difficult due to the high level of purification required.
While both cycloastragenol and astragaloside IV are derived from astragalus herb, cycloastragenol can also be obtained from astragaloside IV through hydrolysis process.
These two compounds have a similar chemical structure, however, cycloastragenol is lighter in molecular weight than astragaloside IV and is also more bioavailable.
The Mechanism of Action of Cycloastragenol
i. Telomerase activation
Telomeres are nucleotide repeats at the ends of linear chromosomes and are bound by a certain set of proteins. Telomeres naturally shortens with every cell division. Telomerase, a ribonucleoprotein complex consisting of catalytic reverse transcriptase enzymes (TERT) and a telomerase RNA component (TERC) lengthens telomeres. Since the key role of telomeres is to protect chromosomes from fusion and degradation, cells usually recognize extremely short telomeres as damaged DNA.
Cycloastragenol telomerase activation results to lengthening of telomeres that in turn exhibits beneficial effects.
ii. Enhances lipid metabolism
Lipids naturally acts as a store for energy in our bodies. However, too much of these lipids could be detrimental to our health.
Cycloastragenol promotes healthy lipid metabolism through various lipid metabolism biomarkers.
First, at low doses, CAG reduces cytoplasmic lipid droplets in 3T3-L1 adipocytes. Secondly, when used at high doses, CAG hinders the differentiation of 3T3-L1 preadipocytes. Finally, CAG can trigger calcium influx in 3T3-L1 preadipocytes.
Since high intracellular calcium can suppress adipocytes differentiation, CAG brings about a balance in lipid metabolism by stimulating calcium influx.
iii. Antioxidant activity
Oxidative stress is the root cause of many diseases and also cell senescence. Oxidative stress occurs when there is an excess of free radicals in the body.
Cycloastragenol exhibits anti-oxidative properties by enhancing the antioxidant capacity. This antioxidant activity is related to the hydroxyl group found in CAG.
Furthermore, oxidative stress is the main cause of telomere shortening, thus CAG telomere protection is derived from both antioxidant activity and telomerase activation.
iv. Anti-inflammatory activity
While inflammation is a natural means by which the body fights against infection or injury, chronic inflammation is harmful. Chronic inflammation is associated with many disorders such as pneumonia, diabetes, cardiovascular disorders and arthritis.
Cycloastragenol powder exhibits anti-inflammatory properties. The anti-inflammatory benefits of cycloastragenol are through various ways including inhibiting lymphocytes proliferation and improving AMP-activated protein kinase (AMPK) phosphorylation.
Benefits of Cycloastragenol
i.Cycloastragenol and immune system
Cycloastragenol can help improve the immunity through boosting the proliferation of T lymphocyte. The ability of cycloastragenol supplement to activate telomerase enables it to stimulate DNA repair while leading o growth and elongation of telomere.
ii.Cycloastragenol and Anti-aging
Cycloastragenol anti-aging properties are the main interest of most research today. CAG has been indicated to delay aging in humans as well as reduce signs of aging such as wrinkles and fine lines. Cycloastragenol anti-aging activity is achieved through four different mechanisms. The cycloastragenol anti-aging mechanisms include;
- Fighting oxidative stress
Oxidative stress occurs naturally when there is an imbalance between free radicals and antioxidant in the body. If not controlled, oxidative stress can accelerate the aging process as well lead to chronic conditions such as cancer, cardiac disorder and diabetes.
Cycloastragenol astragalus extract is an excellent antioxidant compound and also improves the capacity of the naturally existing antioxidants. This helps delay aging and also prevent the occurrence of age-related disorders.
- Cycloastragenol acts as a telomerase activator
As discussed in the above section about mechanism of action, cycloastragenol helps lengthen telomeres. This plays a vital role in ensuring continuity of cell division thus delaying aging. This also helps in keeping the body organs functioning properly.
- Cycloastragenol offers protection from UV rays
When one gets exposed to sunlight for extended periods of time the body cells can get damaged and as result fail to work well. This results to a form of premature aging referred to as photo-aging.
Cycloastragenol powder comes to the rescue as it is shown to protect the skin from the harmful effects of the UV rays.
- Cycloastragenol inhibits protein glycation
Glycation is a process by which a sugar such as glucose or fructose attach to a lipid or a protein. Glycation is one of the biomarkers for diabetes and has been associated with aging as well as other disorders.
Cycloastragenol supplement helps prevent aging due to glycation by inhibiting the formation of glycation products.
iii.The Other Potential Health Benefits of Cycloastragenol:
- Cycloastragenol cancer treatment
The cycloastragenol cancer cure potential is shown by its ability to destroy cancerous cells, improve immunity as well as protect one from harmful reactions of chemotherapy.
In a study of people with breast cancer, cycloastragenol cancer treatment was demonstrated by its ability to reduce mortality by about 40%.
- May protect the heart against damage
Cycloastragenol may provide protection against cardiac dysfunction.
In a study of rats with induced heart damage, cycloastragenol supplementation was found to ameliorate heart dysfunction by promoting autophagy in myocardial cells as well as suppressed the expressions of matrix metalloproteinase-2 (MMP-2) and MMP-9.
- Better sleep
Based on cycloastragenol reviews, it could improve the quality of sleep. However, clinical studies would be required to provide solid evidence on its ability to enhance sleep.
- May help fight depression
Shortened telomere has been found in persons suffering from depressive disorders such as mood issues and diseases such as Alzheimer’s.
In a study of mice in a forced swim test, cycloastragenol supplement administered for 7 days was found to reduce their immobility. It was demonstrated to activate telomerase in neurons as well as in PC1 cells, which explains its anti-depressive potential.
- May accelerate wound healing
Wound healing is a major issue in diabetic patients. This process of wound healing occur through a series of activities. These activities are; inflammatory activity, clotting, restoring of epithelium, rebuilding and finally regulation of stem cells. These epithelial stem cells are critical in diabetic wound healing.
It is demonstrated that telomere degradation negatively affects wound healing. This where cycloastragenol powder comes in to repair shortened telomere as well as enhance proliferation and movement of the stem cells. This in turn helps in fast wound repair.
- Improve hair health
Cycloastragenol reviews by personal users show that cycloastragenol might help prevent hair loss, promote hair growth and enhance hair color.
More cycloastragenol astragalus extract benefits are;
- Offers anti-viral activity against human CD4+ cells.
- Boosting energy.
- Improves skin health.
- Might improve vision.
The Standard Dose of Cycloastragenol
This standard cycloastragenol dosage should be increased in elderly persons of over 60 years to achieve adequate telomere elongation as well as slow the aging process.
Is Cycloastragenol safe?
Cycloastragenol powder is generally regarded as safe at certain dosage ranges. However, since it a fairly new supplement the possible cycloastragenol side effects are not yet known.
The few cycloastragenol reviews on the said benefits of cycloastragenol are not conclusive enough to warrant it rationale use.
In addition, there are concerns that cycloastragenol supplement could accelerate cancer by promoting the growth of tumors. This is a theoretical speculation based on the fact that cycloastragenol main mode of action is through telomere elongation. It is hence thought that it would improve cancer cell growth.
Where can We Get the Best Cycloastragenol?
Well, cycloastragenol powder for sale is readily available online and in various nutritional stores. However, always research for cycloastragenol powder for sale from approved and reputable cycloastragenol suppliers to ensure you get highly purified cycloastragenol.
Cycloastragenol powder has been demonstrated to possess many beneficial effects and more so cycloastragenol anti-aging properties. Cycloastragenol telomerase activation is the main mode of action which in turn increase telomere. These has been demonstrated in many animal models and also a few invitro studies.
Clinical trials of cycloastragenol astragalus extract effect on lengthening telomere are very few and thus more studies to give a solid evidence are required.
The potential effect of TA-65 in ameliorating cardiac dysfunction is very shallow as very limited studies exist in support of this TA-65 action.
Studying the metabolism of cycloastragenol in details would also improve on the available data as well as expose any cycloastragenol toxicity that may occur due to excessive accumulation.
Further studies to evaluate the efficacy of cycloastragenol supplement in the benefits stipulated. The cycloastragenol side effects are yet not known. Therefore, research should be directed to determining the possible cycloastragenol side effects as well as interactions with other medications.
In understanding the cycloastragenol health benefits, it will help explore the mechanisms underlying these CAG actions.
In addition, the appropriate cycloastragenol dosage requires more studies to evaluate the recommended dosage for different age groups. Different cycloastragenol suppliers prescribed different dosages which should be harmonized through research.
- Yuan Yao and Maria Luz Fernandez (2017). “Beneficial Effects of Telomerase Activator (TA-65) Against Chronic Disease”. EC Nutrition 6.5: 176-183.
- Wang, J., Wu, M.-L., Cao, S.-P., Cai, H., Zhao, Z.-M., & Song, Y.-H. (2018). Cycloastragenol ameliorates experimental heart damage in rats by promoting myocardial autophagy via inhibition of AKT1-RPS6KB1 signaling. Biomedicine & Pharmacotherapy, 107, 1074–1081. doi: 10.1016/j.biopha.2018.08.016
- Sun, C., Jiang, M., Zhang, L., Yang, J., Zhang, G., Du, B., … Yao, J. (2017). Cycloastragenol mediates activation and proliferation suppression in concanavalin A-induced mouse lymphocyte pan-activation model. Immunopharmacology and Immunotoxicology, 39(3), 131–139. doi:10.1080/08923973.2017.1300170.
- Ip F, C, F, Ng Y, P, An H, J, Dai Y, Pang H, H, Hu Y, Q, Chin A, C, Harley C, B, Wong Y, H, Ip N, Y: Cycloastragenol Is a Potent Telomerase Activator in Neuronal Cells: Implications for Depression Management. Neurosignals 2014; 22: 52-63. doi: 10.1159/000365290.
- Yu, Yongjie & Zhou, Limin & Yang, Yajun & Liu, Yuyu. (2018). Cycloastragenol: An exciting novel candidate for age‑associated diseases (Review). Experimental and Therapeutic Medicine. 16. 10.3892/etm.2018.6501.
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