From the clinical scene to the business arena, both flmodafinil and modafinil prove to be efficient for boosting the cognitive functions. Being wakefulness-promoting agents, Afinils will help you ace through the graveyard shift.
Forget about the inborn IQ or innate intelligence! Smart drugs have been all the rage for almost three decades now.
I know you’re probably questioning why you should shell out on a pricy stimulant when you can reasonably pay for an amphetamine. Well, this article will give you a bearing on whether to settle for a smart drug or decide on the usual caffeine, which won’t shake your bank account.
Before I delve into the details, you ought to understand that our nootropics only rouse the central nervous system. However, other stimulants fire up motor coordination. This aspect is part of the reason why amphetamines and caffeinated drinks ignite critical withdrawal symptoms such as agitation, euphoria, and exhaustion.
So, how do vs modafinil reviews compare? Let’s find out.
Both flmodafinil and modafinil are nootropics related to hydrafinil, adrafinil, and fladrafinil. We traced their history back to 1986, when the pioneer company, Laboratoire Lafon, filed a patent application in France. Adrafinil was a precursor for these two eugeroics.
The Lafon researchers coincidentally discovered modafinil powder in 1976 as they were looking into adrafinil. By 1994, the company released the compound in the market as the French authorities had approved of it.
Four years later, the US Food and Drug Administration had endorsed modafinil in the treatment of narcolepsy. What is more, it has been a prescription drug for patients with shift-work sleep disorders, daytime hypersomnia, and obstructive sleep apnea.
You’ve probably not have heard about flmodafinil. Well, this is the newest eugeroic of the afinil group of drugs that have been hitting the headlines since 2013. The substance has been under investigation since 2015. Quick access to clinicaltrials.gov confirms that there is an ongoing human trial on the smart drug.
Flmodafinil is otherwise known as CRL-40,940 powder. Although its structural formula appears slightly similar to modafinil, the compound has two fluorine groups attached. This feature is possibly the reason why flmodafinil is also called bisfluoromodafinil. Other alternative names include lauflumide, bis-(p)-fluoromodafinil, and N-deshydroxyl fladrafinil.
Raw CRL-40,940 is identified with CAS number 90280-13-0 while modafinil powder is represented by 68693-11-8.
Since CRL-40,940 (90280-13-0) and modafinil exhibit comparable effects, their mechanism of action is identical. The only notable difference is the two fluoro-groups affixed in the flmodafinil structure, which increases the nootropic’s bioavailability.
These nootropics act on specific neurological transmitters, including dopamine, histamine, norepinephrine, orexin, serotonin, and glutamate. Not only do the smart drugs hold back the dopamine reuptake but also maintain their optimum levels in the brain. The dopaminergic system is responsible for mental focus, wakefulness, and cognitive functions.
The precise therapeutic mechanism of action of flmodafinil and modafinil remains unclear, especially for the treatment of narcolepsy and sleep disorders. CRL-40,940 selectively inhibits dopamine reuptake in the hypothalamus. The work of these afinils on the chemical neurotransmitters results in heightened arousal, agility, enhanced cognition, alertness, and improved mood.
Both CRL-40,940 flmodafinil powder and modafinil exhibit similar neurological effects. After all, the former is a derivative of the other.
The sole reason why modafinil was invented was to cure and manage narcolepsy. Clinically, health providers would recommend it to patients with obstructive sleep apnea, hypersomnia, and people who are struggling with shift-work sleep disorders. Besides, it’s a prescription drug for fibromyalgia and multiple sclerosis. Flmodafinil is the newest version of modafinil powder.
Capitalists and top moguls give these nootropics a go in a bid to boost their business productivity. Next time you want to put on hold some weighty errands due to weariness or sleepiness, you should think twice. A modafinil 200mg scoop is enough to keep you awake and magnify your thinking capacity as you tune into the odd shift.
If you’re a student with a challenging exam ahead, you can confidently ace it with flmodafinil or modafinil dosage. However, you should note that the FDA has ruled out the off-label use of pharmaceutical stimulants.
The two smart drugs boost physical and mental energy, promote alertness, and work on your mental focus. Multiple research studies also suggest that afinils increase the working memory enhance emotional health by boosting your mood.
Both CRL-40,940 (lauflumide) and modafinil have neuroprotective properties. Several studies suggest that the two are significant in the overall neurological health. What is more, they act as dopamine reuptake inhibitors hence boosting up agility, mental focus, and increase in physical energy. Most users also report that smart drugs work efficiently as an anti-depressant and ADHD medication.
So, do flmodafinil benefits differ from modafinil effects?
Well, what sets them apart is the high bioavailability present in flmodafinil. This aspect has made most users speculate that the drug is fast-acting. Although there’s no scientific backup, a significant percentage of CRL-40,940 Reddit reviewers vouch for it more than they endorse other afinils. Every user believes that the drug is an improved version of traditional modafinil.
Occupationally, the military forces of the UK, the US, India, and France legally use modafinil as an alternative to weak amphetamines. The armies and even the astronauts administer the drug when undertaking lengthy missions that would have them sacrifice their sleep.
Both flmodafinil and modafinil are available in capsules, powder, and tablet or pill form. Due to the compounds’ high solubility, you can easily dissolve in water or any other solvent.
A typical modafinil dosage ranges between 100mg and 200mg daily. The dose hinges on the user’s tolerability, health status, and body weight. Some fanatical users could do up to 400mg. When I schemed through the modafinil reddit reviews, I puzzled out that most users kick off with 50mg to 200mg.
Flmodafinil dosage lies between 50mg and 100mg though some people extend it to 200mg. Since the drug’s bioavailability is higher than that of modafinil, more of it is absorbed into the circulation. Therefore, the doses are lower than those of other afinils.
I recommend taking the smart drug once a day, preferably in the morning. You surely don’t want to interfere with your regular circadian cycle. Ensure to stick to the prescribed dosage so that you don’t play the victim of the adverse side effects.
For modafinil, the onset time is about two hours. The plasma concentration of the drug is at its maximum within six hours and drops within two hours. After administering this nootropic, you’ll stay agile for about 12 to 15 hours before you can start feeling sleepy.
CRL-40,940 kicks in less than an hour and peaks between three to six hours. A typical flmodafinil tablet has a short half-life. Therefore, your sleep cycle will remain regular. One user admitted that he could still doze off six hours after administering CRL-40,940. Contrary, on modafinil, it took him a 12-hour period before he could catch a nap.
If you’re to go by the reviews on the online forums, you’ll discover that users prefer CRL-40,940 over modafinil because flmodafinil side effects are few. However, these are mere speculations since the results of the 2015 phase I human study have not been out.
Typical flmodafinil and modafinil side effects are nervousness, headaches, nausea, irregular heart rhythms, and allergic skin reactions. You are at more risk of the adverse reactions if you administer high doses of the nootropics.
In case you don’t take the modafinil or flmodafinil sublingual tablets on time, you’ll possibly struggle with insomnia. For instance, administering modafinil later in the afternoon may affect your regular sleep pattern. You might stay awake until midnight.
However, flmodafinil psychonauts extol CRL-40,940 due to its short half-life that allows users to administer the drug comfortably later in the day.
Besides the individual’s health status and tolerability, other medications could also ignite some of the negative upshots. Take, for example, modafinil interactions with hormonal contraceptives would reduce the efficiency of these family planning drugs. What’s more, the afinils would decrease the activity of cyclosporine, Sandimmune, and Theophylline.
Most states require you to have a valid prescription for you to purchase modafinil legally. Due to insufficient data, CRL-40,940 has no limitations in some countries. Most flmodafinil eBay vendors only sell the raw powder for research and study reasons.
Among the prevailing modafinil warnings, addiction is one of them. For this reason, the US classified it as a schedule IV substance.
In the US, for example, FDA has barred drug companies from marketing modafinil for off-label use. CRL-40,940 is unregulated in the USA and Canada, but it’s a prescription medication in Europe. So, if you’re already a European flmodafinil psychonaut, note that the law is on your neck.
Other nations that have classified modafinil as a controlled substance include China, Russia, the UK, Japan, and Australia. For these states, the possession of smart drugs is stringently forbidden, and it’s subject to seizure at the Border Control Units. However, if you’re on a prescription, you can walk around scot-free.
In the sports and athletic arena, the World Anti-Doping Agency (WADA) has prohibited modafinil use since 2004.
You can acquire these two nootropics either locally or in online stores. Since modafinil buy is illegal in almost every other country, you’ll need a valid doctor’s prescription. So, you should have a compelling reason to give your pharmacist for them to recommend this drug.
One drawback of locally buying flmodafinil or modafinil is that you might not find them in the pharmacy. If you do, please come prepared for breaking the bank.
The surest flmodafinil source is through online vendors. Allow me to explain.
Virtual sellers rarely need a prescription. Some of these stores operate in countries where modafinil and flmodafinil buy have loose medication laws. Moreover, you can choose to buy the generic versions of the smart drugs at a cut-rate price than the popular brand name options.
Well, if you want excellent nootropic deals, check in with us. We give detailed info about all our products so that you can weigh the risks over the benefits of using them. What’s more, you can bank on our services and a dedicated team because we produce our compounds with over 98% purity with HPLC testing.
Log on to our site and revel in our affordable rates. The raw powder form is majorly for research, while modafinil or flmodafinil tablets are for therapeutic applications.
Both CRL-40,940 and modafinil are excellent cerebral stimulants. Most forums stand up for the high bioavailability of flmodafinil. However, no scientific study or clinical study has backed up positive flmodafinil effects. Besides, the patent company has been mum about the success or failure of phase I of the human trial.
Besides potency, the ultimate advantage of CRL-40,940 and modafinil over amphetamines is that they don’t give rise to withdrawal symptoms. The addiction is less and almost negligible. However, FDA used this aspect against modafinil and limited the prescribed dose to only 50 tablets per unit.
For bioavailability, flmodafinil is our champ. It is fast-acting, hence, will be eliminated from the body just in time for your regular circadian cycle. Unlike modafinil, whose half-life extends to 14 hours, flmodafinil is excreted from the system by the eighth hour.
Which one do you prefer between these two? Well, I strongly vouch for modafinil because it bears the FDA’s endorsement as a clinical prescription drug. Unlike flmodafinil, which have no scientific and human study back up, modafinil has widely-known therapeutic applications. Why take a risk with CRL-40,940 when you can still revel in the positive modafinil effects?
- Penaloza, R.A. Sarkar, U., Claman, D.M., and Omachi, T.A. (2013). Trends in On-Label and Off-Label Modafinil Use in a Nationally Representative Sample. JAMA Internal Medicine.
- Mereu, M., Bonci, A., Newman, A.H., and Tanda, G. (2013). The Neurobiology of Modafinil as an Enhancer of Cognitive Performance and a Potential Treatment for Substance Use Disorders.
- Ballas, C.A., Kim, D., Baldassano, C.F., and Hoeh, N. (2002). Modafinil: Past, Present, and Future.Expert Review of Neurotherapeutics.
- Eric Konofal. (2013). Patent US 20130295196 A1 – Lauflumide and the Enantiomers Thereof, Method for Preparing Same and Therapeutic Uses Thereof.
- Gerrad, P., and Malcolm, R. (2007). Mechanisms of Modafinil: A Review of Current Research. Neuropsychiatric Disease and Treatment.