Everything about Semaglutide
|1. Semaglutide Reviews|
|2. Semaglutide Mechanism of Action|
|3. Semaglutide Effects researched so far|
|4. How should we use Semaglutide?|
|5. Semaglutide Side effects|
|6. Order Semaglutide Online|
Many people around the globe are using Semaglutide for its safety and efficacy in treating many conditions. It has been in the market for quite some time and everyone who has used it can attest that it isn’t an average drug. In this article, you will get to read some of our client’s feedback regarding Semaglutide use. Once you read them, you can tell the likeliness of this drug working for you. You’ll notice that Semaglutide reviews are numerous and in all, it has proven to be effective. Here are some of the Semaglutide reviews we have gotten from clients who buy Semaglutide from us.
Bai says, “When I turned thirty last year, I looked myself in the mirror and couldn’t believe that the person looking back right at me was myself. I looked old, tired and almost all my clothes couldn’t fit me. I decided to start my journey to weight loss. Where could I begin? I sought information about weight loss online and came across Semaglutide that seemed to have many positive reviews. I started doing Semaglutide research and decided to buy it from Phcoker.com. Ever since I ordered the drug from them, my body is becoming smaller and more appealing. I am no longer the foodie I was, and I now have less appetite and food cravings. For the last three months, I have lost nine kilograms. Other than having a healthy weight, all my fashionable clothes can now perfectly fit me, and they have never looked this good on me. Anyone struggling with weight should use this. You will love it.”
Chen says, “In the past, I thought that Type 2 Diabetes only occurs to those who had advanced in age until I got diagnosed when I was twenty-three. I felt low and couldn’t imagine that I was going to lose my toes to this monster disease. I tried making positive lifestyle changes in a bid to lose weight. It included getting a nutritionist whom I worked with closely and following a fitness regimen too. All these didn’t seem to make much change in my life, and my doctor kept telling me that I was prone to suffer from stroke and heart attack. It affected me so much physiologically, and I remember almost passing out during a meeting with my workmates. My colleagues got so concerned, and one of them told me aboutSemaglutide as a Diabetes medication. With no many options, I decided to give it a try, and I can confidently say that it has greatly helped me. Semaglutide use has significantly reduced the thirst and tiredness I used to feel. It has been two months, and my diabetes is now under control. Together with healthier eating and exercise, the Semaglutide injection has helped me live a normal life. Thank you Semaglutide.”
Tahiya says “If you are very keen on service providers you will notice that most of them do not give good customer service. I love feeling appreciated as a customer, and the first thing that comes to my mind when dealing with a service provider is the way they are treating me. I have recommended and continue to ask anyone in need of Semaglutide or the other drug to buy it from Phcoker. It is a fantastic site that delivers beyond one’s expectation. For the couple of times that I have bought from them, I have received my package on time. Besides, they are not too pricey, and their products are of high quality. Place your order with this customer-oriented site, and I can assure you that you will never look for any other Semaglutide supplier.”
Semaglutide mechanism of action is through the alteration of the way the pancreas works. Semaglutide works by sensitizing the beta islet cells found in the pancreas which in turn reduces the amount of insulin secreted as a response to carbohydrate intake. Additionally, it suppresses the release of postprandial glucagon from the alpha cells also found in the pancreas. In other words, we can say thatSemaglutide works by regulating the postprandial glucose level.
Another of the Semaglutide effects is the delayed emptying of the gastric and suppression of appetite. As a result, people who are on Semaglutide may lose a significant amount of weight. Since the Semaglutide mechanism of action is glucose dependent, it is not likely to make one suffer from hypoglycemia.
You will notice that Semaglutide has been very beneficial in the world of medicine. The Semaglutide effects has made researchers move a stride forward in the search treatment for various conditions. From the Semaglutide reviews that users have given, you can tell that it is widely used for the following Semaglutide effects.
(1) Semaglutide’s Role in the GLP-1 Agonist
Semaglutide is a glucagon-like peptide-1 receptor agonists which people also refer to them as GLP-1 agonists. It is one of the potent GLP-1 agonist that has been approved for human use. They usually works as incretin mimetic which copy or rather mimics the way natural incretin hormones work in the body. These hormones work by lowering post-meal blood sugar levels. They do this in the following ways;
- It reduces the speed in which glucose is absorbed into the bloodstream. It is made possible by decreasing the speed at which the stomach gets empty after one takes a meal. It makes one feel fuller for a more extended period after eating.
- It inhibits the release of glucagon which is released in the pancreas. The primary function of glucagon is to stimulate the release of stored sugar by the liver into the bloodstream.
- It stimulates the release of insulin after a meal. The pancreas can release the insulin even before the blood sugar starts rising.
The GLP-1 agonists are used to treat type 2 diabetes and are better than insulin secretagogues because they have a lower risk of causing hypoglycaemia.
Also Semaglutide research shows that GLP-1 agonists has a lower stroke risk compared to other controls.
(2) Oral Semaglutide on Patients with Type 2 Diabetes
Type 2 diabetes is one of the most prevalent conditions today and dealing with it can be challenging. It is brought about by the body’s inability to use insulin as it is supposed to hence not able to control the amount of sugar in the one’s blood. Leading to symptoms of depression and anxiety, it has left many unable to live a normal life. Even worse, after some time people who have diabetes may develop severe, life-threatening ailments like stroke, kidney problems, heart disease, eye problems, and nerve damage.
With the increasing commonness of Diabetes Type 2, many researchers have sought to look for a medication that could help those suffering from it be able to manage it. Many patients are using diabetes medication, checking on their blood sugar regularly and making lifestyle changes like quitting smoking, exercising and maintaining a healthy diet in a bid to manage the disease and improve on their health.
As much as all these may assist in reducing one’s chance of suffering from stroke, heart attack and other conditions that are diabetes related, some drugs have proven to be more effective than others in the fight against Diabetes type 2. Semaglutide injection is the new dawn for anyone who has Diabetes Type 2. Patients who have used this diabetes medication have been able to live a happy and fulfilling life.
The Semaglutide injection is frequently used together with an exercise program and a healthy diet to control the blood sugar levels in grown-ups suffering from type 2 Diabetes. To back this up, the FDA approved the once-weekly injection in the management of Type 2 Diabetes in 2017. It is crucial to note that Semaglutide injection should never be used to treat type 1 diabetes. It is a condition whereby the body is not able to produce insulin thus cannot regulate the amount of sugar on one’s blood. In such a case Semaglutide injection cannot be effective if used in place of insulin injections for patients in need of insulin.
Semaglutide injections are classified as incretin mimetics whereby they assist the pancreas in releasing the correct amount of insulin when the levels of blood sugar are high. Once you decide to use Semaglutide injection, you can be sure that you will now be able to deal with the diabetes type 2 and any other complications like numbness, cold legs, decreased sexual ability, loss of vision and gum diseases that may be caused by this condition.
In a trial done on 458 adults with type 2 diabetes, findings showed that there was more reduction on the HbA with Semaglutide drug treatment compared with the use of dulaglutide. In the randomized study that took fifty-seven weeks, the patients were given 3mg, 7mg, and 14mg of Semaglutide while others were put on 0.75 mg of dulaglutide once a week.
Everyone on the study was tested for tolerability; safety and efficacy for oral Semaglutide and together with those under the dulaglutide medication were also administered with one oral diabetes medication. It was reported that during the study, oral Semaglutide demonstrated better tolerance and efficacy compared to the subcutaneous dulaglutide.
The Semaglutide side effects reported during the study were constipation and nausea. The percentage of people that were treated with 3, 7 and 14 mg Semaglutide and who suffered from the gastrointestinal adverse effects were 31%, 39%, and 54% respectively while 40% of those on dulaglutide suffered from it. At week 52, there was a more significant reduction in body weight and HbA with 14mg oral Semaglutide as compared to the 0.75mg of dulaglutide.
Another thing that makes Semaglutide injection stand out as diabetes medication is that it reduces the risk of diabetes patients from suffering from cardiovascular events. In a study done which involved more than three thousand people with type 2 diabetes and who were considered to be at a higher risk of suffering from cardiovascular complications showed that it effectively lessens the chance. The group was divided into two groups and half of them administered with 14mg of Oral Semaglutide while the others were on placebo. Researchers were very keen on checking how the drug affected the major cardiovascular events, e.g., a death that is as a result of a cardiovascular condition.
The results showed that there was a 21% reduction in the risk of suffering from cardiovascular-related health complications on anyone who took the oral Semaglutide. Also, there was a 49% reduction in the overall mortality rate through the use of Semaglutide.
Although dealing with Type 2 Diabetes can be quite challenging, it is not a condition that you have to live with. Get the medication from the best Semaglutide supplier which is Phcoker.com and lower your blood sugar levels.
(3) Semaglutide may help people to lose weight
Are you struggling to shed some weight to no avail? Do you want that flat tummy desperately and nothing seems to give you the desired results? If so there is still some hope for you. Excessive weight comes with a lot of health problems, and it could increase the number of hospital visits you make. Some of the health problems that are caused by being obese are high cholesterol, high blood pressure, sleep apnea, and heart disease to name a few. Other than negatively affecting your health, it makes you look unattractive; something that could make you lose your confidence. We all can agree that losing the saggy fat and getting a perfect shape and a healthier figure could make you walk shoulders high even when all eyes are on you.
Making some lifestyle changes don’t work on everyone. Eating less and taking part in more physical activity isn’t just enough to lose weight. Even after working out too hard and sticking to your nutrition plan, you may not achieve your desired results. It may assist in shedding some fat, but the process may be too slow that you may find yourself getting impatient. People who have been dealing with weight issues are always on the lookout for something fast, easy and effective. Due to this many people have fallen in the trap of using unhealthy diets. Those that value good results and health will always go for the Semaglutide weight loss effect.
The good thing with Semaglutide is that it will always keep your hunger at bay and your cravings in line. You know what this means especially when you want to set off on a vacation that you have been eagerly waiting for. You might be worried about how much weight you might gain after eating all the delicious foods that you are possibly going to come across during the vacation. The solution for all this is taking Semaglutide because it will ensure that you feel full and do not have to keep snacking all the time.
A random study done showed that Semaglutide induced the most significant weight loss effect in people who had obesity but not Diabetes as compared to any other pharmaceutical medication. The Semaglutide research involved 957 people, whereby 35% of them were males. Everyone in this study had a BMI of more than 30 and were not suffering from diabetes. They were randomly placed in seven groups and five of them administered with different dosages of Semaglutide injection once daily. The dosages ranged from 0.05 mg and 0.4 mg. The sixth group was given a placebo while the seventh received 3mg of a diabetes drug known as Saxenda. During the study, all participants were given the appropriate advice regarding exercise and diet that they were to adhere to.
After twelve months, all participants who were on Semaglutide had lost more weight compared to those receiving placebo. It was noted that the higher the Semaglutide dosage, the higher the average weight loss. For participants who were receiving 0.05mg of this medication daily, an average of 6.0 of their body weight was lost. The one that received 0.1mg Semaglutide lost an average of 8.6% of their body weight, while those that were administered with 0.3mg lost an average of 11.2%. Those that received a daily dose of 0.4mg lost an average of 13.8 % of the body weight while those that were on liraglutide lost 7.8 % of their body weight. The remaining group that was on placebo lost 2.3% on average
It was also noted that 65% of the participants who were on 0.4 mg of Semaglutide daily lost a minimum of 10% of their body weight compared to the 34% and 10% in the liraglutide and the placebo group respectively. It is evident that Semaglutide, when combined with proper diet and exercise, could give a significant dose-related reduction in weight for patients who are struggling with weight management and who do not have diabetes.
From the Semaglutide reviews, you will notice that this drug is capable of helping you deal with weight more effectively as compared to some weight drugs. If you want to lose weight well, then the use of Semaglutide is worth a try.
(4) Other effects of Semaglutide
If you want to use Semaglutide for other reasons other than those mentioned above, you should consider talking to your doctor first.
(1) Oral Semaglutide
There are those with injection phobia who will opt to go for the oral Semaglutide. Semaglutide research shows that both the oral and the injection are efficient. Oral Semaglutide is taken once daily with a dosage of 2-20mg. However, there are those who prefer taking a high dosage of 40mg.
(2) Semaglutide Injection
When you want to start using Semaglutide injection, begin with a 0.25 mg subcutaneous injection to be given weekly for four weeks. The main aim of this dosage is to initiate treatment and not for glycemic control. From the fifth week, you can increase the dosage to 0.5mg per week.
In case you need additional glycemic control after administering 0.5mg of Semaglutide for four weeks then you could consider increasing the dosage to 1mg once weekly. You should, however, note that this is the maximum recommended dosage for this medication.
Semaglutide injection is administered subcutaneously either on the upper arm, thigh or abdomen. For every time you inject the drug, you shouldn’t use the same site on the same body region. For instance, if you did a thigh injection this week, you should not get a jab on the same part of the same thigh.
Before administering it inspect it visually. What this means is that you should check if there is a change in color. It should always be clear and colorless, and if you notice any particulate matter or coloration, then you should dispose of it.
If you are also on insulin, then you should give them as separate injections and never mix the two. It is safe to inject them on the same body part like the thigh but not too adjacent to each other.
If the day that you’ve been getting the injection administered is inconvenient for you, you can change it as long as the duration between the last administration and the next is at least forty-eight hours.
If you miss a Semaglutide dose, take it as soon as you remember. Do this if five days are not over since you missed it. If it’s past five days, do not administer it; wait for the next scheduled dosage and get the injection. In both cases, you should resume to your regular once-weekly dosing schedule.
You are advised to have a Semaglutide injection once weekly on the same day of every week and at the same time of the day regardless of whether you have taken a meal or not.
Never share your Semaglutide pen with anyone else even if it may seem safe once you change the needles. It should be avoided because it poses a risk of transmitting blood-borne pathogens.
Just like any other medication, Semaglutide has potential side effects too. The important thing to note is that not everyone will experience them. Some people taking Semaglutide have never experienced any of the said side effects at all. Some factors like pre-existing conditions or drugs that you may be on might increase the severity.
A majority of people may be wondering which side effects Semaglutide could cause them. Here are some of the possible side effects caused by the use of Semaglutide;
- Low blood sugar (hypoglycemia) – Once you start using Ozempic, you might be at the risk of suffering from hypoglycemia, a condition symptomized by feeling jittery, having a fast heartbeat, headache, weakness, shakiness and confusion and drowsiness. It may also lead to hunger, slurred speech, sweating, irritability and mood changes, anxiety, dizziness, and lightheadedness. The risk of suffering from this goes up if you use Semaglutide together with other drugs that cause low blood sugar. Examples of such medication are insulin and sulfonylurea. It is therefore useful to check how other medicines that you may be taking could interact with the use of Ozempic. If you are using insulin or sulfonylurea, then you have to reduce its dosage to lessen the risk of suffering from hypoglycemia. If you suffer from low blood sugar (hypoglycemia) and you want to treat it quickly, then get a fast-acting source of sugar such as non-diet soda, raisins, crackers, hard candy or fruit juice. Also, a doctor could recommend a glucagon emergency injection kit that you can administer to yourself in case you suffer from acute hypoglycemia, and you are not able to eat or drink.
- Severe allergic reactions- For some people, Semaglutide side effects may include difficulties while breathing, rash and itching. You are advised to stop using the medication and seek medical help right away.
- Kidney problems (kidney problems)- There have been reports of kidney injury or worsening of pre-existing renal failure which could sometime necessitate hemodialysis for patients who have been treated for GLP-1 receptor agonists. Monitoring of how your kidney is functioning while on this medication or when escalating its dosage is very crucial.
- It could cause thyroid tumors and cancer too-In case you notice that you got a lump or swelling around your neck area, shortness of breath, hoarseness or trouble swallowing after the use of Semaglutide, then you need to see your doctor.
- Inflammation of your pancreas- Also known as pancreatitis, swelling of the pancreas is one of the Semaglutide side effects. Ozempic could cause a feeling of severe pain in your stomach area or abdomen. You may also feel the pain emanating from your abdomen to the back.
- Changes in vision
- Have reduced frequency in the number of times that you urinate. You may also notice that your legs, feet, and ankles are swollen.
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As much as it may seem easy, I know that there is a tide of queries and doubts running in your mind. How quick will I receive my Semaglutide? I hope it will not be counterfeit! After how long will I see the Semaglutide effects? These are a number of the countless questions that come to our minds, and that scares us when you are just about to order anything online. It is normal to have such issues crossing your mind because nobody wants to lose their body or ruin their health by buying fake products. You have to be very careful when you decide to buy Semaglutide online because not everyone is trustworthy. Some may not care about your well-being and this might be unsafe for you.
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- Semaglutide Versus Dulaglutide -Once Weekly in Patients with Type 2 Diabetes (SUSTAIN 7): a Randomised, Open-label, Phase 3b Trial, Richard E. Pratley, Vanita R. Aroda, Ildiko Lingvay, Jorg Ludemann, Camilla Andreassen, Andrea Navarria, Adie Viljoen Elsevier, 2018.
- Handbook of Incretin-based -Therapies in Type 2 Diabetes, edited by Stephen Gough, page 80-88.
- Semaglutide, Reduction in Glycated -Haemoglobin and the Risk of Diabetic Retinopathy, Tina Vilsboll, Stephen C. Bain, Lawrence A. Leiter, Ildiko Lingvay, David Matthews, Rarael Simo, Ida Caroe, Helmark, Nelun Wijayasingye, Michael Larsen, John Wiley $ Sons Limited, 2018.