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Nootropic Source Bromantane Reviews, Effects, Dosage
Fat Loss

Nootropic Source Bromantane: Reviews, Effects, Dosage

1. What is Bromantane?

Bromantane (87913-26-6) was initially known as Ladasten and is a derivative of adamantine. It was first developed in laboratories and pharmaceutical companies in Russia back in the 1980s.  The exciting thing is that research done on petroleum solutions is the source of the adamantane discovery. It is then that researchers started striving harder to research on polyhedral organic compounds and the way they are synthesized.

At that time scientists were looking for an antiviral drug that could help in curing influenza and through many trials and studies, they noticed that adamantine and its derivatives acted as dopamine receptors and could, therefore, be classed as stimulants. The discovery was seen as a medical breakthrough because the substance could be used in some clinical applications.

Bromantane has become popular among many nootropic users over the years with many soldiers and athletes using it since the late 80s. Bromantane exerts a stimulating and anxiolytic effect at the same time. Although the two effects seem to negate each other’s effects, you need to note the fact that Bromantane is an excellent nootropic because it is a mental relaxant and a stimulant all in one.

It has been used to enhance recovery after tedious physical activity. It is still in the research process to determine whether it can be used in sports medicine because many people who have used it in the past have reported that it has significantly increased their athletic performance. It is also said to increase one’s alertness as well as their motivation and the overall mental energy.

In 1996, Bromantane got banned after it was noticed that some athletes were using it so that they could stand out and beat others in the Olympic Games.

2. Bromantane Mechanism of Action

The Bromantane mechanism of action depends on the serotonergic and dopaminergic neurotransmitter systems. By now you can already guess how it works. Its effects are brought about by the sense that Bromantane inhibits the reuptake of both dopamine and serotonin. Though it is still not known how it increases the norepinephrine in the body, it is suspected to do so. Additionally, the anxiolytic properties that Bromantane exerts are as a result of the way it strengthens the GABA-ergic mediation.

As a result, Bromantane has unique properties compared to other nootropics in the market. Through the Bromantane mechanism of action, it can increase the effect of the lower centers of the central nervous system especially the hippocampus and the hypothalamus nuclei.

Once there is an increase in amino acid decarboxylase and tyrosine hydroxylase, there is more formation of dopamine from tyrosine. More dopamine in the brain means that there is an increase in wakefulness and alertness.

Also through the increase of serotonin in the body, you will notice that there is a rise in the feeling of happiness.

Usually, it is broken down in the liver, and the adrenal gland eliminates it. Since it prevents the body from overheating, it helps in replenishing the body after exertion. Subsequently, it significantly enhances your exercise regimen as well as relieves you from stress.


Nootropic Source Bromantane Reviews, Effects, Dosage


3.Bromantane’s reasonable dosage

It is always good to the correct Bromantane dosage because just like other substances taking too much comes with its repercussions. For instance, if you decide to take a very high dose so that you can remain alert, you may end up feeling sleepier. And even in some cases having an overdose could lead to one suffering from the severe side effect that could end up affecting your day to day activities. Very low doses, on the other hand, will not give you the results that you desire, and you may end up thinking that Bromantane (87913-26-6) doesn’t work for you. To prevent you from going through this here is some advice for you;

First, take it slow until you have known how your body reacts to its use and how much it can endure. The Bromantane effects start kicking in from as low as 10mg, and your dosage will, therefore, depend on what you want to achieve. As a starter, you could start by taking it once a day before graduating to using it twice daily.

Another thing you ought to know is that the Bromantane dosage is sex-dependent since it is absorbed fast in female users. The Bromantane half-life is much shorter in women as compared to men. Females take about 2.75 hours to start feeling the Bromantane effect while it takes men four hours to feel the same effect. Since it is highly lipophilic, this nootropic is absorbed fast by the gastrointestinal tract once taken orally.

The average Bromantane dosage starts at 50-200mg and any dosage that exceeds 300mg is not recommended. Typically many people prefer to take 100-200mg daily divided twice in a day to mean that one takes a dosage of 50-100mg during morning and evening. Using this for the next two to four weeks will help you realize your ideal results.

4.Bromantane Stacking

When we talk about stacking, we are referring to taking a combination of different supplements to achieve better results. Most stacks feature supplements that have different purposes to achieve all of them during the stacking period. The advantage that comes with Bromantane is that it is quite versatile and it can either be taken solely or in combination with other supplements. Here are some of the common Bromantane stacks and the synergistic benefits that they offer.

  • Bromantane, Agmatine, Kava Kava, AcetylCarnitine and Fish Oilstack

Here is one of the most potent Bromantane stacks that improve health, stimulation, motivation while at the same time decreases anxiety.

  • Bromantane, Citalopram, Clomipramine, Liothyronine, and Agomelatine stack

This stack is also powerful in ensuring that it gives you the attentiveness and wakefulness that you need.

5.Bromantane effects

(1) Bromantane Benefits

  • Relieves anxiety and stress

Sometimes you may be going through mental fatigue and may feel like you’ve reached your breaking point. During this moment, you feel like happiness is very far from your reach. It is normal, and the good news is that taking Bromantane helps you cope with this feeling and get your life back. Some of the Bromantane benefits are that it promotes the sense of relaxation, increases the body’s resistance to stress and could also help replace brain chemicals that may be depleted by stress. As a result, once you take Bromantane, you will no longer experience any uncomfortable moments of stress and anxiety.

  • Increases endurance

Those who use Bromantane can admit that it helps them gain more stamina when performing their activities. For instance, a distance that seemed challenging now feels a bit easier. It does not only benefit marathoners but anyone who indulges in physical activity. You will realize that with the use of the Bromantane supplement, you can now do more with a lot of energy and strength for an extended period. Consequently, you will be amazed at how much you will be able to achieve without feeling extremely tired. So if you are interested in taking your endurance levels a notch higher, ordering Bromantane from Phcoker.com should be the next thing that you should do.

  • It restores and increases mental and physical working activity

Throughout the years, our psychological and physical working activity may reduce because of aging and other factors. Luckily, Bromantane can help you restore that in a jiffy. By increasing the rate at which the muscle tissues can recover from vigorous physical activities, the body’s physical working activity is enhanced. As for the mental working activity, you will be able to think critically and make better decisions fast without the brain getting sluggish. Subsequently, you will always remain mentally sharp and not experience brain fog anymore.



  • Resistance to overheating

Once the body produces more heat than it releases, it may lead to hyperthermia or overheating. As a result, you may be at the risk of suffering from severe illnesses. One of the Bromantane effects is that it prevents the body from overheating and thwarts hyperthermia.

  • Anxiolytic effects

At one point in life, everyone has undergone anxiety. Feeling the fear or worry may be rare or constant affecting one’s life negatively. To avoid going through such distress, you could opt to take Bromantane.

  • It promotes energy and eliminates fatigue

You know the feeling that you get when you are just from work and need to attend your gym session. Most probably your energy levels are at their minimum and just lifting your legs could be quite a task. Fatigue not only affects the way we handle our physical activities but it also negatively impacts your social relationships, family life and how you behave at work. While many people may not know how to deal with it, taking Bromantane is one of the effective solutions to curb fatigue.  If you feel like you might need an energy boost enough to last you the whole day then taking Bromantane supplement is the best thing to do. Bromantane gives you more energy without over stimulating you even when you feel like you are worn out and sluggishness is catching up with you.

  • It improves learning processes and the coordination of movement

When we talk about improving the learning process, it means that the ability to comprehend new things is enhanced. Bromantane makes you a more effective and efficient learner. Also, it improves muscle movement coordination, and this could play a significant role in improving sports performance.

  • Promotes the body’s immune system

Who wouldn’t want to have a good immune system? Having an enhanced immune system helps your body respond to an infection in the best way possible. What’s more interesting is that from the first dose of Bromantane that you take, your body can fight illnesses in a better way than it could earlier on. The improved immunity is due to the increase in the level of the B-cells in the body. They are the white blood cells that help the body in fighting off diseases. That means that with the use of Bromantane, you get enhanced protection against diseases and infection. Order Bromantane from us today and wave the frequent hospital visits goodbye!

  • Increases memory

Have you been in a situation that you cannot recall something that happened minutes ago? It could be stressing, and you might find yourself wondering which medical procedure could improve this. The good news is that Bromantane helps with memory storage and memory retrieval. The advantage of this is that you can always recall things that you need to. It dramatically improves both short term and long term memory thus enhancing your ability to remember.


Nootropic Source Bromantane Reviews, Effects, Dosage


  • Liver detox

Since the liver is a vital organ in the body, it needs to be taken care of. It plays a significant role in getting rid of impurities and toxins and also supports healthy digestion through the production of bile. Sometimes it could get overworked and detoxing it is the best thing that could ensure it is still functioning well. Bromantane has proved to detox the liver hence keeping it working in its best condition.  Liver cleansing also comes with some benefits including weight loss, enhancing the immune system support and improving on a person’s overall health. So if you may want to make a change for the better taking Bromantane could be an excellent start for you.

  • Increase in muscle strength

Those who are into fitness and everybody else should look forward to achieving muscle strength because it is essential for good health. Even better once you have muscular strength, you can lift weights, open heavy doors without getting tired. It also decreases the risk of getting injured when undertaking your daily activities. But how do you add on your muscular strength? Taking Bromantane is one of the effective ways that will assist in increasing your muscle strength.

  • Nonaddictive with no withdrawal symptoms

 What this means is that Bromantane doesn’t make your body dependent on the chemical. According to studies done, once you stop taking it, it will cost you practically nothing because you will not be addicted to it. Unlike some supplements that are habit-forming, this one is not addictive and will not trigger any withdrawal symptoms once you decide to stop using it.

  • Few side effects

When taking any supplement or medication, it is normal that you run the risk of suffering from side effects. The difference comes in the severity of the effects. Some supplements may make you suffer from very severe side effects which may end up affecting the quality of your life, i.e., cancer, stroke, heart attack or organ transplant rejection while others may be mild. As for Bromatane, it will offer you all the benefits without putting your health in jeopardy.  Therefore, you will be able to manage the side effects efficiently and never at any one time will they affect your daily activities.

  • It may help with reproduction

There have been studies done on male mice, and they showed that Bromantane increased their sperm count and enhanced the sperm movement too. In female mice, it assisted in preventing embryo loss. Additionally, it raised the sex drive in the rats which could be caused by the dopamine activity of this supplement.

We could rely on this study since human beings have a similar genetic make-up as the rodents. And with many people suffering from reproduction issues nowadays, Bromantane could be the breakthrough for them.

  • Bromantane could help in the treatment of Neurasthenia

Neurasthenia is a condition that makes one suffer from insomnia, mental weariness, and fatigue. In a study done on asthenia patients, taking a low Bromantane dosage reduced the symptoms and helped them get some sleep. Also, it improved their quality of life, and only 3% of the patients experienced mild side effects.

Bromantane ensures that if you are feeling drowsy, it keeps you awake while it increases your consciousness when you are awake.

  • It may reduce inflammation

In a study done on mice, Bromantane effectively reduced depression-caused inflammation. It achieved this through by decreasing the levels of these inflammatory cytokines;

  • TNF-alpha
  • IL-4
  • IL-17
  • IL-6


(2) Bromantane risks

In every supplement that you decide to use, you run the risk of suffering from a reaction as well as enjoying the benefits. What’s important is that you must weigh the possible risks against the positive effects before deciding whether to take the supplement. In our case, Bromantane benefits seem to outweigh the risks. Most of the Bromantane effects are positive with very few people suffering from Bromantane related issues. What may increase the severity of the side effects is taking a very high Bromantane dosage. If you take a lower dosage, you also get to decrease the risk of suffering from severe side effects. Here are some of the Bromantane effects that could be caused by its use.

  • Taking a high dosage of Bromantane has been suspected to lead to an increase in the DNA-binding action of the beta-amyloid precursor protein which is associated with the pathogenesis of the Alzheimer’s disease. It is good to note that this study was done with around sixty-eight times higher dosage than the standard dosage prescribed.
  • Once you use Bromantane for an extended period, you may suffer from brain fog or headaches especially if you are used to taking more than 200mg of it. Some people have also reported that they felt light-headed after taking daily.
  • It could cause digestive upset to some people. That could be symptomized by having an uncomfortable feeling in the stomach, i.e., pains, nausea, etc. To counter that, you could consider taking an over the counter drug.

6. Bromantane User Reviews

Bromantane has been in use for a couple of years, and if the user reviews are to go by, then this supplement does a fantastic job. People tend to react differently with different supplements, but this one tends to score well in all the boxes. Almost all Bromantane reviews are about how much people have had a good time after taking it and the transformation it has made in their lives. Here are some of the Bromantane reviews we have gotten from the clients that have trusted us as their Bromantane source.

Gongfu says, “I just started taking Bromantane a couple of weeks ago, and all I can say is that I like it! First of all, it has ridiculously boosted my confidence and motivation. My self-esteem is high, and I am always looking forward to starting a new day. I feel like a new being and not only has it made my life happier but it has also made me achieve so much in the recent past. I am now able to talk to my clients with more confidence than I could, and I have noticed that I am making more sales than I made last year. Being a painter, I am now able to do my job with more energy and stamina, and I feel like this supplement will continue to boost my career. The Bromantane experience is genuinely good, and I would recommend this supplement to anyone who wants to make a change in their lives.”

Huang says, “My job entails doing a lot of reports, and I recently started experiencing brain fog. I could often lose concentration and focus, and meeting deadlines became a real problem. I was always in problems with my seniors and to make it worse I received a warning letter. I felt so helpless and decided to google and see if I could get any help. Luckily, I bumped into Bromantane supplement from phcoker.com, and I entrusted them due to the reviews that showed that they were one of the best Bromantane suppliers globally. True to it, I do not experience any difficulty concentrating or focusing. Even after working till late, my boss always commends me. I almost lost my job, but I now got a promotion thanks to Bromantane.”

Ling says,” I have struggled with memory loss for as long as I can remember. Sometimes I even couldn’t recall which day of the week it was. It was quite disturbing because I kept losing my stuff once I forgot where I placed them. Worse still, this condition made me drop out of college because I kept on failing my exams even after studying too hard. Not until a friend suggested that I should use Bromantane and I decided to give it a try. It has been a month, and my memory has improved. I remember most of the important things that I should, and I now feel young again. My friends no longer have to keep reminding me of the obvious things. What makes me glad is that I am back to school and so far I have performed well in my cats. If you feel like memory loss is taking a toll on you, this is the solution.  So what could you be waiting for? Order Bromantane from Phcoker and get the help you need.”


Nootropic Source Bromantane Reviews, Effects, Dosage


Wang says, “Bromantane has helped me fight depression, and I no longer use any other medication. My family and friends were almost giving up on me because sometimes I could experience unexplained sadness and I could later become suicidal. I had tried almost all drugs you can think of, and I felt like I had hit a dead end. I remember that day when my counselor mentioned something to do with Bromantane, and I didn’t take it lightly. To cut a long story short, my relationship at work and socializing with friends has greatly improved. My Bromantane experience is fantastic, and I would recommend it to anyone who is fighting depression.”

Juan says, “I wish i knew about this drug years ago because i wouldn’t have suffered as I did. I always got stressed up when the night started setting in because I knew that I I would struggle falling and staying asleep throughout the night. At times anxiety would catch up with me, and I could cry all night. Even after so many hospital visits, nothing seemed to change. My sister brought me Bromantane, and I have been taking 100mg daily for the last month. I wouldn’t thank Bromantane enough because since then sleeplessness and anxiety have reduced greatly, and I now take a nap without experiencing any disruptions. I now feel calm, and I have never enjoyed my nights

Hui says, “I am a bodybuilder and since I started using this product I have realized a lot of gains especially on the muscle strength. I can now lift heavier weights with more vigor without hurting myself. My muscles are growing bigger every day, and everyone keeps looking at my ripped body. I will be placing my order soon and would ask any bodybuilder who looks forward to looking good to buy Bromantane.”

Cheng says, “So the other day I decided to shop look for genuine Bromantane suppliers online. I got a couple of them, and I just wanted to settle on the best. I narrowed down to three of them and decided to give them a test. I contacted them and asked them about their delivery options. Guess what happened? Only one site didn’t send an automated reply. Phcoker.com sent me a detailed reply that left me awed. Their customer care is top notch, and I felt at peace placing an order with them. Within a few days, my order was delivered, and I will tell you about the results within a month. If you want to buy from sellers that value their customers, this is the place to be.”

7.Bromantane source online

With the Bromantane reviews that you have read, you probably could be interested in buying it. But how do you purchase it? While you might not be sure whether you are going to find Bromantane in your local store, purchasing it online could help you a great deal. Luckily with the use of the internet, you can compare prices, reviews and order for supplements without leaving the comfort of your home.

What you ought to know before buying the internet is that all sites are not safe. You need to be very careful, or you might put your health at risk. Worse still you will have wasted your money and time from the purchase. The reason is that you may buy Bromantane that is counterfeit and with its use, you can be sure that you are not going to achieve anything. Other products may be expired, and this reduces their effectiveness. Sometimes fake Bromantane suppliers may want to defraud people by selling supplements that have overstayed by taking advantage of the fact that the transactions are done online.

You may also find out that you bought a particular supplement that had been stolen and resold. As much as it may be useful, you don’t want to be promoting a site that thrives from stealing from others. While the supplements may appear to be too cheap, you need to be extremely diligent not to avoid getting exploited.

We don’t want you suffering from all these, and that’s why we advise you to use the only trusted site Phcoker.com. We have very many reasons why you should buy from us, and we will give you some of them.

We are reliable sellers where you can buy Bromantane, and we will ship it to your location. We sell high-quality Bromantane that is free from any additives or fillers. So Bromantane safety is not something that you will need to worry about. Our Bromantane is manufactured through the state of the art processes, and it will undoubtedly give you the results that you deserve in the shortest time possible.

As for our prices, we are affordable, and you will not have to dig deeper into your pockets to buy Bromantane. We also ensure that you get value for your money by making sure that you but effective Bromantane in the best price globally.

We offer a customer-centered shopping experience to ensure that every buyer enjoys a hassle-free buying experience. Our clients’ satisfaction comes first, and it is our goal to see all of them get the best. Our customer care is always ready to listen to your complaints, suggestions, and recommendations and this is what in a realm above all our other competitors.

Our deliveries are safe, reliable and fast. Once you order Bromantane from us, we dispatch your parcel in the shortest time, and the time you get, it depends on your location. Buy Bromantane from us today and start your journey to good health.



  1. Chemical Abstracts, Volume 139, Issue 1, Part 1, American Chemical Society., 2003, page 94
  2. Oliynyk, S., $ Oh, S. (2012). The Pharmacology of acro protectors: Practical application for improvement of mental and physical performance. Biomolecules and Therapeutics, 20(5), 446-556
  3. Krapivin, S. V, Sergeeva-S. A., $ Morozov, I. S. (1993), A quantitative pharmaco-electroencephalographic analysis of the action of bromantane, 116(11), 515-8
How Does Synephrine HCL Work On Your Body?
Fat Loss

How Does Synephrine HCL Work On Your Body?

Synephrine HCL (5985-28-4) Facts


Synephrine (5985-28-4) is an alkaloid that is commonly used to form the supplement Synephrine HCL. This article includes the Synephrine facts, Synephrine history, synephrine HCL mechanism of action, health benefits of synephrine, potential side effects/risks of synephrine and synephrine recommended usage.

Synephrine History

The use of Synephrine (Cas: 5985-28-4, known as para Synephrine, or p-Synephrine) dates back to many years ago and can be traced back to the native China. The medicinal value of Synephrine was discovered in the region where it first used to treat gastrointestinal ailments such as nausea and constipation. Also, the ancient Brazilians used Synephrine as a remedy to sleeplessness, anxiety and convulsions.

How Does Synephrine HCL Work On Your Body?
The bitter orange tree, found in Asia and Mediterranean.

The following are some of the common facts that everyone who intends to use Synephrine should know about the fruit from which the chemical is derived from(bitter orange fruit) :

  • The fruit also contains other chemicals among them being ephedrine. The concentration of the latter substance is however very little.
  • Bitter orange fruit has been in existence for long and its use stems back to native Asia where it was mainly used to treat stomach complications. It is also highly available in parts of Eastern Africa.
  • Traditionally, bitter orange was used to treat nausea, constipation, and indigestion. In the Mediterranean, it was used to treat heartburn, promote weight loss and decrease appetite.  Its oil extracts were sometimes applied to the skin, but it has mostly been used in its extract form.

Confusions surrounding Synephrine

Synephrine powder has for long been confused for other substances that are similar to it. This confusion has been so serious that even some reputable scientific journals find it difficult to establish where to classify this chemical appropriately. Some of the substances that are similar but yet different from Synephrine include the following:

  • Bitter orange extract. This is primarily the source of Synephrine.  However, many people are still not aware that other than this chemical, there exist other substances in the extract that are similar to Synephrine yet very different in terms of their modes of action. For this reason, the bitter orange is known as a reliable solution for the treatment of various diseases and the chemicals responsible for the treatment of these ailments are different from p-Synephrine.
  • Phenylephrine. This chemical is structurally very similar to Synephrine, but their modes of action are ways apart. While Synephrine is used for improving the body’s metabolism through thermogenesis, phenylephrine is primarily used as a nasal decongestant. The chemical phenylephrine is also used in surgical operations to dilate the eye’s pupil during an operation. Phenylephrine is made synthetically. On the other hand, Synephrine, is obtained from plant extracts.
  • Ephedrine. The bitter orange fruit has also been found to have significant reserves of this Ephedrine. Ephedrine is a very strong stimulant and whose use must be controlled as it is strongly addictive.

The structure of the stimulant ephedrine is similar to that of Synephrine, and this is primarily the confusing bit of the two chemicals. However, the use of ephedrine is prohibited in many places for its adverse effects to humans, especially if you take Synephrine without control. On the other hand, use of Synephrine doesn’t carry any similar side effects, and it is thus considered to be a safer option as compared to ephedrine.

How Does Synephrine HCL Work On Your Body?

Current Synephrine use

Presently, Synephrine and Synephrine supplements are used for a variety of purposes among them being for the improvement of the body’s metabolism. The stimulant enhances the process of thermogenesis through which the excess fats in the body are broken down to form muscles.

The body responds to this by adopting a leaner well-built look. The stimulant also helps people to maintain a healthy appetite and support a proper metabolism.

How safe is Synephrine HCL Powder?

The safety of Synephrine HCL powder has not been widely doubted as it is the case with other stimulants. This is because the drug has been tested repeatedly and it has been found to be harmless especially if one uses the appropriate dosage.

The most widely anticipated side result after use of any stimulant is the development of high blood pressure which is often accompanied by fast unusual heartbeat rate. However, the use of Synephrine will deliver different side results. This makes it a different and better option to the significant performance-enhancing drugs that are in the market today.

However, some studies show that a combination of caffeine and synephrine HCL powder is likely to cause potentially fatal cardiovascular effects. Nevertheless, other researchers have ruled out such possibility.  We are going to see about that debate here later on.

FDA has not issued any warning concerning Synephrine consumption. In fact, in some countries, the use of Synephrine in the place of ephedrine is highly encouraged. This is due to the safety concerns that are often raised when using ephedrine which is a very powerful stimulant. This makes it a likely precursor for high blood pressure and increased heartbeat rate.

How Does Synephrine HCL Work On Your Body?
Get positive synehrine (5985-28-4) reviews from obese

Synephrine Reviews

Synephrine HCL powder’s use has generated numerous reviews. While there are a few negative ones, most people have been pleased by what the supplement has helped them achieve especially those who desire to lose excess body fats. Some of the things that they say include the following:

James Shaw : James Shaw is a 44-year-old who lives in Liverpool, England. He says,” I’ve been overweight for some time now, and the issue has been stressing me a lot especially when I remember the well-built body that I had during my early thirties.  I’ve also been suffering from high blood pressure for about five years now and have always feared using a supplement as my problem could worsen.”

“ I was at first given a dosage of 20mg per day, and this was gradually increased as the doctor kept accessing my situation. Luckily, nothing lethal happened within the period and my body improved to the extent that I never expected. Today, I can happily walk without feeling shameful about my body appearance. I’d recommend the use of Synephrine to anyone who’s having weight issues without having any doubt about the result.” She adds.

Katlego Muphulukuzi: Katlego Muphulukuzi is a 29-year-old from South Africa. After using Synephrine, this is what he has to say,” My love for junks went down immensely from the time I started using Synephrine supplements. I also feel more energetic than ever before. I enrolled in the local gym, and within six months, my physique had also changed much; I look more beautiful.”

Paul McLaughlin works at a chemist in Chicago, Illinois: “I’ve been a retail chemist for seven years. In the beginning, we were selling ephedrine, and that was one of the fastest selling drugs in the shop. The scene however changed when the State drug control board came at us for retailing a banned substance. We had to eliminate ephedrine from the shelves or else the chemist would have been shut. After this, great uncertainty came as to how the chemist would run without one of the most widely consumed commodities.

He adds that, “Just while still in this moment, word went round that Synephrine was the new thing to replace ephedrine. I never personally thought that anything could replace ephedrine but the reviews that I got from the customers made me pause to think. People came demanding for the supplement at an alarming rate. The most surprising thing was that even those who I never thought that they could use such a stimulant also came. Some even came with medical prescriptions to buy the supplement.

Our sales tripled in less than a year and up to now, Synephrine is the most bought supplement on the chemist. I’d recommend everyone who has overweight issues to use the drug. I won’t do that to boost my sales. It’s because I’ve experienced what one is set to reap from using the supplement.” Paul is currently on Synephrine. “

Sharon: “I wish I could be able to post my photos before and after the time I started to use Synephrine. I have finally managed to get my dream shape and I’m very happy about it. I would recommend Synephrine to anyone who wants to lose weight without struggling.”

Paul Luol Deng: Paul says, “I’ve had a hard time especially with ladies who want to shed some weight. Unlike men, they are always reluctant to use steroids as they fear that they may affect their reproductive system.”

He add, “I’ve been using Synephrine for long, and they’ve worked well for me. One day, a friend from the US visited my gym and advised me to try Synephrine HCL supplement on my female clients. This didn’t require so much convincing as it is a supplement, unlike the steroids that I tried getting them on earlier. The first few clients were enough to convince the rest about the effectiveness of the supplement. It worked miracles, and they shed excess weight so fast as I combined their dosage with a little caffeine to make it faster. These days, everyone wants to get on this magical supplement even the men.”

Emily: “I’m extremely appreciative to Phcoker for the Synephrine supplements they sent me two months ago. My appetite has reduced and I have begun to experience some significant changes in my body as far as weight is concerned. So far so good.”

Vanessa Ford : Vanessa Ford says, “There’s no better mood booster than Synephrine HCL. At first I thought it was a weak stimulant that would not give me any better feeling than taking my coffee. However, some sixth sense told me to try it out. I made my first purchase, and after beginning the dosage, things started being different. I was all at once energetic that my gym instructor was left wondering where the extra motivation had come from. I’ve continued to use the supplement to date, and all that I can say is that there is no better mood booster than Synephrine HCL.”

Fredrick: “I have managed to shed over five kilos for the last one year, thanks to the  magical Synephrine supplement. I can’t thank enough the friend who introduced me to them. They are the best fat burning supplements I know.”

What is Synephrine(5985-28-4)?

Synephrine Description

Synephrine(5985-28-4) is an alkaloid that is commonly used to form the supplement Synephrine HCL.


Synephrine is derived mostly from the bitter orange fruit that is highly concentrated in the chemical. However, this fruit is not the only known source of the alkaloid. Other citrus fruits such as lemons have also been found to have Synephrine powder although it exists in minute amounts.

Synephrine is a good fat burner and help with weight loss. It can also increase blood pressure and this can be a concern to those with heart problems.

Mechanism of Action of Synephrine HCL powder

The Synephrine mechanism of action explains the various effects that the supplement induces many in the body. The following are some of these effects through which the body ultimately regains a different shape on the bodybuilding front:

1. Effects of metabolism

This is the primary mode of action of the chemical. The drug will increase the rate of thermogenesis. This is done in the liver, and the yield is usually increased energy to the body that is the ultimate desire of any athlete.

The action of Synephrine was conducted on mice, and the following effects that are also similar to what happens in humans were observed:

  • There was an increased breakdown of glucose and glycogen. These are the key sources of energy in the body. Their breakdown is therefore expected to bring a new transformation in the energy yield.
  • Sugars that were present in the mice’s body were not converted to fats. For any bodybuilder, gaining of fats is the last thing that they would wish for. Instead, everyone wants to burn the excess fats and convert it to muscles.
  • This conversion happens at an improved rate when an energy giving supplement is used. This makes Synephrine a valuable supplement for any performance enhancing athlete.
  • The amount of ATP present in the mice’s liver was significantly increased. This conversion is beneficial in improving the rate of chemical reactions in this body organ. When the rate of action is improved, the breakdown of fats occurs at a more rapid rate than before.
  • More glucose in the mice body cells was consumed. This happens through the stimulating of the enzyme AMPK that is critical in aiding the burning of body fats. The increase in AMPK also leads to more sugar being taken into the body cells where it is broken down to release energy.
  • The action of the enzymes a-amylase and a-glucosidase was inhibited. These are the enzymes that are responsible for the digestion of complex starch in the body. The significance of this process is that the occurrence of post-meal blood sugar spikes is largely inhibited.
2. Stimulatory effects

The use of Synephrine will stimulate the action of alpha 1 and alpha two adrenal receptors, but this happens in a significantly lesser degree to the action of phenylephrine and ephedrine. This means that the chances of an individual experiencing an increased heartbeat rate as well as high blood pressure are highly minimized.

The use of Synephrine will also lead to increased activation of the neuromedin U2 receptors. These molecules are located in the hypothalamus in the human brain and are responsible for controlling sleep. The use of Synephrine will stimulate the receptors causing the hypothalamus to induce wakefulness for longer than normal

3. Anti-inflammatory effects

The use of Synephrine will inhibit the activation of NF-kB. This substance is key in causing inflammatory ailments such as asthma. The use of Synephrine has also been found to affect the action of the eotaxin-1 hormone largely. This prevents the movement of eosinophil to an area that is inflamed.

Although not well proved through experiments, the use of Synephrine has been found to inhibit the action of acetylcholinesterase. This chemical is known to cause Alzheimer’s disease.

How Does Synephrine HCL Work On Your Body?

Health Benefits of Synephrine

While all drugs have their known side effects, they still have advantages when used appropriately. Synephrine has been used for as an alternative to ephedrine. This was after major world drug use regulatory bodies imposed a ban on the use of the latter drug.

Of great concern was the potential for addiction that is likely to arise following the use of ephedrine. Also, ephedrine is an extremely robust stimulant, and it is known to stimulate high blood pressure. Therefore, Synephrine can be used as like for like replacement for ephedrine.

The following are some of the Synephrine benefits that one is set to achieve after appropriate use of the stimulant:

1. Synephrine Weight loss

This is the most apparent issue that many ephedrine users wanted to address when taking the banned drug. Synephrine is as effective as ephedrine in aiding loss of excessive body fats. This will result in weight loss.

The drug also works similarly by causing an improvement of the body’s metabolism. When this occurs, body processes occur at a rapid rate, and excess fats are burned.

The process of fats breakdown is achieved through lipolysis. This involves the influence on receptors that are found in the fat tissues. This will ensure fats breakdown occurs at a faster rate than it would have happened if the individual hadn’t used a supplement.

This process through which excess fats are eliminated and in its stead muscles are generated is known as thermogenesis. It is a naturally occurring process though at a very slow rate.

2. Appetite loss

Most people will have an appetite for at least something that is not nutritionally helpful to their healthy wellbeing. This includes junks such as ice creams, fries, and cookies. Such foods are a thorn in the flesh especially to someone who intends to lose the excessive fats.

This is because the calorific intake determines the rate of fat loss. When so many calories are taken, the process of converting them to muscles rather than fats becomes so tedious for the body.

When one takes Synephrine HCL, the appetite is greatly suppressed. This is advantageous in that one’s crave for junks is put on a check. The individual can now focus on taking foods that are healthy to the body.

Therefore, the use of Synephrine as a supplement for controlling body fats in your body is just the best thing as it’ll ensure you achieve this through all means.

3. Better muscular glucose uptake

The use of Synephrine will promote the uptake of glucose by the body. This happens in two main ways. Excess glucose in the bloodstream fats retention is a probable occurrence.

Use of Synephrine will ensure that the excess glucose in the blood is eliminated and transferred to the skeletal muscles. Here the glucose can be easily converted to muscles.

Secondly, Synephrine will ensure that the transfer of glucose to the skeletal muscles results in energy build up as the sugar will be swiftly broken down. This energy is critical for driving key metabolic processes that will enable the individual to lose excess fats.

4. Aids glycogenesis

The liver is the body organ that is tasked with the breakdown of stored fats in the body. Use of Synephrine influences the liver to induce glycogenesis. This significant process would otherwise occur at a very slow rate. What Synephrine HCL does is to hasten the process of lipolysis.

5. Helps in control diabetes

When the body is slow in burning the excess sugar in the body and converting it to a useful form, the chances of diabetes developing are high. The use of Synephrine can be a solution regarding setting the body’s glucose levels within the allowed limits. When used, the supplement derived from bitter orange fruits encourages the breakdown of the sugars to release energy.

Individuals who have used it have tested lower blood sugar levels, and this is proof of the drug’s capability to controlling diabetes.

6. Improved digestion

Individuals who have supplemented using Synephrine HCL have had minimal cases of indigestion during the period of use. Also, the effectiveness of the drug on this front hasn’t been scientifically backed.

However, the claim has high degree proof given that the bitter orange fruit from which Synephrine is primarily derived from has been used for so long to control stomach upsets.

7. Reduced  nervousness before surgery

This use has also not been scientifically proved to be true beyond reasonable doubt. However, individuals who have used Synephrine before a surgical operation have been found to have minimal nervousness. The drug enables the individual to have a calm attitude that is desirable especially before a major operation.

8. Improved moods and energy levels

The use of Synephrine has been found to cause a significant change in the mood and energy levels of individuals. According to a study that was conducted, this benefit of the drug was proved. Mice were subjected to a variety of conditions to establish the effect of using the drug.

This resulted in a behavioral change that affected even their feeding habits. After some time, healthy stress-free mice were put in water and prompted to swim alongside ones that were depressed. The stressed mice were very sluggish during this phase.

They were then put under Synephrine and their activity notably improved. In the same manner, individuals who have used the supplement are highly likely to be in high spirits as compared to ones who haven’t used it. The energy levels of Synephrine supplement users have been found to be highly improved than normal.

9. Control of harmful bacteria

Some people use the drug like an antibiotic, and it has proved to be helpful to some extent. For instance, its use has led to minimizing the levels of bacteria such as E. coli in the body. The effectiveness of the drug on this has however not been fully proven.

11. Minimized inflammation

The supplement is highly effective in minimizing the probability of inflammation on an injured body part. The drugs act by significantly reducing the number of inflammatory cells and cytokines. This is followed by activation of anti-inflammatory molecules in the affected cells.

The presence of inflammatory molecules directly accelerates many allergic diseases such as asthma. The use of Synephrine aids in reducing the concentration of NF-kB that is harmful in its activated state.

The drug is undoubtedly the best replacement for ephedrine as it will address all the areas mentioned above like the banned stimulant. It also does so in a clean manner as its side effects are significantly less lethal as compared to ephedrine which is known to cause high blood pressure even when used in low dosages.

For best results, it is advisable to avoid buying the drug from chemists directly. Instead, one should visit a qualified medical practitioner who will deliver the right advice on how to use the drug safely and achieve what is desired.

Potential Side Effects of Synephrine

The use of Synephrine is also accompanied by side effects just like any other drug. However, the probability of them being pronounced is highly dependent on the dosage that is used.

The effects are also highly likely to be rampant when one does couple the use of Synephrine together with caffeine. The following are some of the Synephrine HCL side effects that are experienced by the users of the supplement:

  • High blood pressure

No stimulant is considered to be 100% safe regarding causing high blood pressure. Although Synephrine is deemed to be a safer option than ephedrine in this front, it also carries the potential for causing high blood pressure.

The risk is however minimal. It is advisable to avoid taking the supplement if you’ve had had cases of high blood pressure.

  • Heart disease

As it is the case with high blood pressure, Synephrine cannot be considered to be as lethal as ephedrine in causing heart disease. However, theirs is a chance of the condition developing or escalating especially if it is used together with caffeine.

Nonetheless, there’s still an ongoing debate about the possibility of the stimulant to cause or trigger a heart disease, with some studies showing that it doesn’t have any cardiovascular effect if used alone or together with caffeine.

  • Irregular heartbeat

Stimulants work by increasing the rate of body metabolic processes. Usually, this is accompanied by an increase in the heartbeat rate as the heart strives to get as much blood as possible to the body organs. The use of Synephrine HCL powder is likely to cause an increase in the heartbeat although this is rarely experienced.

However, using the stimulant together with another drug of the kind such as caffeine is likely to heighten the problem. In such a case, the heartbeat may even become irregular, and this can be fatal as it can lead to death when not handled early enough.

  • Fatalities if used in high dosage just before surgery

This drug is used by some people to minimize tension before surgery. This effect is usually achieved, but it is only safe at very low concentrations. When the dosage is high, use of Synephrine HCL before surgery is likely to cause high blood pressure or cardiac arrest.

This might lead to death if the issues develop during an operation. Therefore, it is advisable to avoid Synephrine or any other stimulant before an operation.

In some cases, a doctor may prescribe the drug to be used before the procedure begins. In such a case, it should be done with strict adherence to the medic’s directive lest it develops to a problem during the operation.

  • Hallucinations

The use of Synephrine high dosage is also likely to cause hallucinations, considering that it is a stimulant.

Other side effects

People who use Synephrine supplements experience other side effects. However, the severity of the effects vary from one individual to the other and depend on many things with the dosage used is key. Some of these effects include:

  • Formation of blood clots
  • Kidney failure has also been reported. However, this occurs specifically to individuals who have had kidney problems.
  • Chest pains. This symptom might be confused with physical pain resulting from muscle stress during a workout session.
  • This will only happen following an overdose or a combination with another very powerful stimulant.
  • Thrombosis

The above-mentioned side effects should however never limit one on taking the supplement. Research has shown that the probability of any of the symptoms being highly pronounced is very low and will only happen when a large Synephrine dosage is used.

There is limited information regarding the influence of the drug on breastfeeding mothers as well as the expectant ones. It is therefore advisable to stay away from using the drug at such a time as one may not know what will develop after use.

Synephrine Recommended Usage

Synephrine is contained in many bodybuilding supplements in varying amounts depending on the manufacturer’s preference. The most commonly used dosage is about 100mg per day. This is considered to be enough dosage capable of achieving weight loss.

Although most people generally apply the above-mentioned Synephrine dosage, it is usually on the upper limit of what is considered to cause an effect on the user. A dosage of as low as about 30mg is enough especially for beginners.

For individuals who use the supplement together with other kinds of stimulants, the  dosage should be kept as low as possible for compatibility purposes. This is because the use of Synephrine together with a stimulant such as caffeine may predispose the user to high blood pressure and increased heartbeat rate. Though, as mentioned earlier, this is a subject that is still on debate.

The recommended amount that even the conditioned users should not exceed is 200mg per day. Anything above this mark is considered to be toxic and will put the individual at risk of experiencing a raft of the fatal side effects associated with stimulants use. It is advisable, to begin with, 10 to 20mg to ensure that Synephrine is seamlessly compatible with your body.

After taking this initial dosage, you should take time to assess the body’s response to the supplement. If all is well, the second dosage of about 20mg can be added after two hours.

The safest dosage interval is taking the drug once every two hours. It is, however, advisable to refrain from taking the drug about four hours before sleep. The supplement usually takes about two hours to become effective in the body.

Therefore, taking Synephrine as you close in on your sleep is likely going to interrupt with your body. You will probably be unable to catch sleep.

How Does Synephrine HCL Work On Your Body?
Taking right synephrine dosage for weight loss

Top topics for discussion: Synephrine vs Caffeine

Is a Synephrine/ caffeine combination safe?

When consumed, Synephrine boosts body’s metabolism while caffeine makes one to be more awake. Some supplements contain caffeine and Synephrine as their ingredients to offer the benefits of the two.

Nevertheless, there has been an ongoing debate concerning Synephrine vs Caffeine;  the use of Synephrine and caffeine. Some studies show that a combination of the two can ends up forming a drug that is similar to ephedrine, and the side effects associated with this drug are also experienced as a result of the blend.

The health assessments released recently by Finland and Germany indicate that a combination of Synephrine and caffeine is likely to increase the possibly adverse effects of increased blood pressure and heart rate. On that note, some European government agencies have ordered the removal of supplements with a combination of the two supplements from the market as a result of health safety concerns.

On the other hand, some studies, for instance BfR Opinion No. 004/2013 titled   “Health Assessment Of Sports And Weight Loss Products Containing Synephrine And Caffeine”, have found that Synephrine doesn’t have any cardiovascular effect if used alone or in combination with caffeine.

Do Synephrine and caffeine offer the same benefits?

Also, there is a section of people who believe that Synephrine and caffeine offer the same benefits. However, it is worth noting that although both are stimulants, their  functionalities are different and so are their effects.

Caffeine affects the central nervous system, digestive system and the circulatory system. The results of caffeine use include alertness, wakefulness and mood boost.  Its side effects include jitters, headache, anxiety as well as irritability.

On the other hand, Synephrine mostly affects your body’s metabolism, resulting in an increased metabolism, energy expenditure and power.

Therefore, Synephrine and caffeine are two different stimulants with varying effects.

Purchase Synephrine Supplement Online

Are you in need of Synephrine supplement? The good news is that you buy Synephrine online, and on the other hand, unfortunately, there are substandard supplements sold online and you might not easily differentiate them from the genuine ones.

In as such, it is paramount that you buy Synephrine supplement from a trusted,  reputable online seller, preferably Phcoker.com.

Here’s the simple steps you’ll follow to buy  Synephrine from Phcoker.com:

Go to Phcoker.com website

  • Search “Synephrine(5985-28-4)
  • Fill the purchase application form correctly and submit
  • In case you are required to fill in a brief short medical questionnaire, do it and submit. Phcoker’s specialist will use the filled out form to establish whether to approve to your order.
  • Pay for the order once it is approved.
  • Wait for the supplements to be delivered to you (for not more than three days if you are in the U.S.)

You see how easy it is to buy Synephrine online?

However, before you buy the supplement, it is advisable that you consult a health care expert for advice on the correct dose to use and for a determination if the stimulant will be safe for you.  The specialist will advise you on the appropriate dose to take and the possibility of developing side effects if you take the supplement.

Conclusion on Synephrine(5985-28-4)

In a nutshell, Synephrine ticks all the boxes of a perfect supplement for use in cutting weight. It has very mild side effects, and this makes it the ideal accompaniment for any athlete who intends to improve their energy levels during a workout session. It has seamlessly replaced the once highly coveted ephedrine and provided an even better alternative for getting one high without the risk of developing high blood pressure.


  1. Akhlaghi, M., Shabanian, G., Rafieian-Kopaei, M., Parvin, N., Saadat, M., and Akhlaghi, M. Citrus aurantium blossom and preoperative anxiety. Rev Bras.Anestesiol. 2011;61(6):702-712.
  2. Bent, S., Padula, A., and Neuhaus, J. Safety and efficacy of citrus aurantium for weight loss. Am.J.Cardiol. 11-15-2004;94(10):1359-1361
  3. Campbell-Tofte, J. I., Molgaard, P., Josefsen, K., Abdallah, Z., Hansen, S. H., Cornett, C., Mu, H., Richter, E. A., Petersen, H. W., Norregaard, J. C., and Winther, K. Randomized and double-blinded pilot clinical study of the safety and anti-diabetic efficacy of the Rauvolfia-Citrus tea, as used in Nigerian traditional medicine. J Ethnopharmacol. 1-27-2011;133(2):402-411.
  4. R. Costa, M.B.A. Glória, in Encyclopedia of Food Sciences and Nutrition (Second Edition), 2003
  1. Ghanim H, Sai CL, Upadhyay M. et al. Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression. Amer J Clin Nutr. 2010;91:940-949
  2. Stohs SJ. Assessment of the adverse event reports associated with Citrus aurantium(bitter orange) from April 2004 to October 2009.
  3. Dragull K, Breksa AP, Cain B. Synephrine content of juice from Satsuma mandarins (Citrus unshiuMarcovitch). J Agric.Food Chem. 2008;56:8874-8878
  4. Roman MC, Betz JM, Hildreth J. Determination of synephrine in bitter orange raw materials, extracts, and dietary supplements by liquid chromatography with ultraviolet detection: single laboratory validation. J Amer Org Anal Chemists Int. 2007;90:68-81
  5. Mercolini L, Mandrioli R, Trere T. et al. Fast CE analysis of adrenergic amines in different parts of Citrus aurantiumfruit and dietary supplements. J Sep Sci. 2010;32:1-8
  6. Haaz S, Fontaine KR, Cutter G, Limdi N. et al. Citrus aurantiumand synephrine alkaloids in the treatment of overweight and obesity: an update. Obesity Rev. 2006;7:79-88
  7. Higgins, J. P., Tuttle, T. D., and Higgins, C. L. Energy beverages: content and safety. Mayo Clin Proc. 2010;85(11):1033-1041.
  8. Kaats, G. R., Miller, H., Preuss, H. G., and Stohs, S. J. A 60day double-blind, placebo-controlled safety study involving Citrus aurantium (bitter orange) extract. Food Chem Toxicol. 2013;55:358-362.
  9. Lynch B. Review of the safety of p-synephrine and caffeine. Intertek-Cantox Report, 2013;1-20.
  10. Health assessment of sports and weight loss products containing synephrine and caffeine BfROpinion No. 004/2013, of 16 November 2012
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