Are you rummaging around for a top-rated protein supplement with loads of therapeutic uses? Find out whether the synthetic human growth hormone is worth the hype. Get to know the HGH benefits, side effects, how the drug works, and its legitimacy as per the FDA standards.
Behind every elite bodybuilder, there’s a secret protein supplement, which you might never get to know. Talk of efficiency, the Human Growth Hormone (HGH) takes the lead.
Although it exhibits anabolic properties, HGH is not merely a steroid like testosterone. This hormone is essential in the well-being of any human as it stimulates several cellular metabolic processes. If you were to describe it vividly, you would have to sum up all the benefits of the other hormones.
HGH is among the few hormonal drugs with valid approval from the FDA. Although some people would incorporate it into their bodybuilding regime, the treatment is significant for therapeutic uses. However, if you were to use it for clinical applications, you will need to have a genuine doctor’s prescription.
This article does not condone the use of HGH bodybuilding supplements, but it gives some insight on what to expect while taking the supplement. Before using the human growth hormone, make sure to flick through this piece.
1. Human Growth Hormone (HGH)
The Human Growth Hormone is a 191 amino acid that naturally occurs in the mammalian body. It is a single-chain polypeptide, which stimulates growth and development. The somatotropic cells within the anterior pituitary gland are responsible for its synthesis, storage, and secretion.
The Human Growth Hormone is made of different molecular isoforms, such as 22-kDa and the minor 20-kDa variants.
The secretion of HGH is dependent on various factors such as sleep, exercise, diet, gender, or age. For example, when asleep, the hypothalamus will trigger the Growth Hormone-Releasing Hormone to stimulate the release of GH. Also, the hormone increases at puberty, during fasting, physical activity, low blood sugar levels, or as a result of physiological stress. Contrary, it decreases with age, body weight, and food ingestion.
HGH secretion is at the peak during childhood and adolescence. Typically, the body of a young person would churn out up to 700μg of human growth hormone per day. Conversely, healthy adults produce a daily average of about 400μg.
It is so mystifying that HGH is high in the early years and tails off as one hits the golden age. The phenomenon has made researchers to investigate the role of this hormone in aging. Seeing that HGH strengthens and improves the musculoskeletal system, there’s a potentiality that the drug can be ananti-aging treatment.
Despite its natural occurrence, there exists a synthetic human growth hormone, which is available as a prescription drug for poor development in children.
1.1 Human Growth Hormone (HGH) History
In the late 50s, the first scientific researchers set out to establish the effect of a monkey’s GH in a 13-year-old boy with hypopituitarism. Later, these scholars conducted the same study on five people with different conditions, alongside a healthy young man who acted as a placebo.
Before the production of synthetic HGH bodybuilding hormone, scientists would extract growth hormones from cadavers and use them for treating deficiencies and short stature. However, this practice came to a dead end in 1985 on the basis that some infectious prions would be transferred to the HGH recipient. There were reported incidences of Creutzfeldt –Jakob disease, and cases of colon and prostate cancer among the individuals who once benefitted from the cadaver-derived hormone.
By 1980, the recombinant DNA technology had set in leading to the commercial production of biosynthetic human growth hormone. Over the years, scores of HGH manufacturers have emerged, but only a handful have received FDA approval.
1.2 Human Growth Hormone Mechanism of Action
The physiological stimulation of HGH consistently occurs in pulses at intervals of about three to five hours during the day. At night while deep asleep, the response is at the peak. The average plasma concentration ranges between 5 ng/mL and 72ng/mL.
When the anterior pituitary gland releases HGH into the bloodstream, it acts in two ways; directly and indirectly.
In the direct mechanism, the hormone binds to the target cells to trigger a growth response in the respective tissues. Being a polypeptide, HGH is not soluble in fats, hence, impermeable to the cellular membranes. As a result, it binds to the receptors of target cells via the MAPK/ERK pathway. This mechanism leads to an increase in gene expression, and therefore, cellular growth, replication, and regeneration.
In the indirect effect, high levels of HGH prompt the release of insulin-like growth factor-1 (IGF-1) via the JAK-STAT cellular signaling pathway. This mechanism takes place in the liver and is initiated by the hepatocytes.
The upregulation of IGF-1 has both physiological and metabolic effects on the body. For example, it facilitates protein synthesis in the muscle cells and accelerates bone growth through cartilage formation. Besides, IGF-1 boosts immunity, offers cardioprotection, and acts as an anti-inflammatory agent.
HGH for muscle gain not only fuels development in children but also tissue repair, metabolism, brain function, and musculoskeletal growth.
1.3 HGH vs. Anabolic Steroids
You are probably wondering why everybody doesn’t seem to be using HGH bodybuilding supplements. Hold your fire because I’ll explain why the drug isn’t a popular anabolic stimulant in the fitness industry.
First of all, the HGH price will have you break the bank. Only elite gymnasts and athletes would take a chance with it. The rest of the population would instead run the risk of using cheap alternatives than shell out for a human growth hormone.
Moreover, most countries have banned the use, production, and distribution of HGH. For, example, in the U.S., the drug is accessible from a genuine HGH supplier subject to a valid prescription.
Let’s face it. We all want instant feedback whenever we take medication. It’s like doing some compound workouts and walking to the mirror an hour later, expecting to see a flat abdomen with defined abs already.
Unlike other steroids, which yield results as early as a week, HGH before and after upshots will show up six to eight months later. Although the long wait may appear to test your patience, the gains are permanent. This aspect is a blessing in disguise.
Lastly, every other person seems trypanophobic, and therefore, would not withstand daily painful injections of GH. Well, this is no longer a fuss since the alternative forms of the treatment include oral administration.
1.4 Doping with HGH
HGH exhibits anabolic properties, which has made the drug tantalizing to the sports community. Doping with human growth hormone dates back to 1980s. However, anti-doping agencies such as NCAA, WADA, and IOC have prohibited its use. Active athletes abusing this drug are not only permanently banned from the Olympics but also face charges.
Although doping with HGH was forbade in the early 80s, the law came into effect twenty years later. The delay was as a result of an unreliable test that would distinguish between endogenous and exogenous human growth hormone. After all, these two have an identical molecular composition with similar effects on the mammalian system.
After the urine analysis failed to detect HGH in the body, research scientists took a shot at developing blood tests. In 2004, WADA analyzed the Summer Olympic Games in Greece. This mode of HGH testing is in use till today.
2. Human Growth Hormone (HGH) Application
2.1 HGH for Bodybuilding
Every bodybuilder looks dreams of gaining lean muscles while at the same time losing the extra body fats. Well, the human growth hormone works the same way. Several clinical trials have proved that the use of recombinant HGH not only accelerated the muscle mass but also burning of fats. The drug is, no doubt an ideal treatment for weight loss for obese patients.
Although studies don’t support claims that GH has a role in performance enhancement, many athletes believe it is magical. Its anabolic effects include an increase in muscle mass, protein synthesis, and body strength. The drug is also responsible for rapid recovery within the musculoskeletal system.
Administering HGH for muscle gain initiates collagen synthesis within the tendons and skeletal muscles. The hormone gives you maximum strength and capacity to endure intense physical activities. Additionally, treatment with exogenous human growth human promotes lipolysis and loss of ugly fats around the belly.
The effect of HGH on athletic performance stirred up the World Anti-doping Agency to list it as a prohibited substance. Therefore, HGH application in sports is illegal, whether you are in or out of the competition.
2.2 HGH for Anti-aging
The world-shattering discovery that wrote off HGH as an anti-aging treatment came as a twist of fate.
According to research published in 1990 by The England Journal of Medicine, the study group registered a significant increase in bone density and lean muscles. The researchers noted that these improvements were contrary to what is expected from adults aged 60 and above. Since this observation was not part of their clinical trial objectives, the scholars did not infer the efficacy of GH as an anti-aging drug.
In 2007, another human trial on healthy adults established that the use of HGH increased the muscle mass of the study group. Besides, there was also a decrease in body fats by almost 4.5 pounds.
This exogenous hormone will not only stimulate mass gain but also spark off the growth of connective tissues. The hard and tight muscles result in a youthful appearance. It’s not yet conclusive that HGH anti-aging reverses aging, but it is evident that the drug slows down the processes that come with old age.
2.3 HGH for Therapeutic Uses
FDA has legalized the use of recombinant Human Growth Hormone in the treatment of various GH-related conditions.
Adults with HGH-deficiency use the synthetic hormone as replacement therapy. A follow up on these patients proved the efficiency of the drug in reducing body fats and building lean masses. Besides, it increases the bone density, trims down the cardiovascular risk factors, and boosts the lipid profile.
HGH for muscle gain is useful in the treatment of short stature, which may or may not have been brought about by insufficient growth hormone. Take, for example, Prader-Willi syndrome, Turner syndrome, intrauterine growth restriction, and chronic failure are managed with recombinant GH. In such cases, the doses are usually high to speed up the cellular regeneration and the healing process.
This hormone is also a prescription drug for patients with muscle-wasting conditions such as HIV/AIDS.
Additionally, administering the synthetic human growth hormone helps boost the emotional, cognitive, and mental well-being of a person. One of the side effects of GH-deficiency is depression. However, taking this treatment is a sure remedy.
2.4 GH for Industrial Agriculture
The application of growth hormone in dairy farming is permissible in the United States. In this industry, GH is used to increase the production of both milk and beef.
3. Human Growth Hormone Benefits
♦ Lean Muscle Mass Gain
Even if you aren’t a gym enthusiast, HGH benefits will make you look like one. The hormone boosts protein synthesis, which is responsible for muscle gain.
Unlike the use of steroids, taking HGH has permanent gains on the user. Once the cycle is complete, there is no need for a post cycle therapy to offset the hormonal balance. The reason is that these gained muscle tissues are retainable. It is no doubt that AAS users would always stack with a growth hormone to magnify the results.
The efficiency of HGH in mass gains has led it to be endorsed as a prescription drug for muscle-wasting in people living with HIV/AIDs.
♦ Aging Reversal
HGH anti-aging supplement will cause your muscles to function like that of a 20-year-old. The drug will not only increase the musculoskeletal masses but also makes them tight, hard, and young.
In old age, the muscles tend to decline while the bone mass decrease. However, a study published in The England Journal of Medicine proved that the hormone led to an increase in muscle size and bone density among the elderly.
Moreover, some physicians in the U.S. are prescribing HGH to the elderly as a means of improving their vitality.
♦ Weight Loss
HGH for weight loss sparks off the hydrolysis of triglycerides into free fatty acids and glycerol. Through the mechanism, extra body fats become water-soluble, which the system can easily flush out. Besides, the hormone reduces the sensitivity of the body to insulin. For this reason, the drug has been prescribed to obese and overweight adults. Averagely, one will lose up to five pounds in a single HGH cycle.
Studies show that obese adults have low levels of human growth hormone than their normal-weight counterparts. This discovery has left scientists speculating whether administering HGH would have an impact on weight loss.
In a complete cycle, a user can lose up to 14% of the total body fat. Well, this figure applies if you are neither dieting nor working out. Those who want to burn substantial weight can subscribe to a fitness regime.
♦ Improved Sleep
HGH is an excellent sleep therapy. If you find it hard to fall or stay asleep, you can give it a go. When you have trouble catching the forty winks due to the effects of anabolic steroids, you should consider this hormone in your stacking cycle.
The release of the human growth hormone is optimum at the onset of deep sleep. Burning the midnight oil, staying up late, or working the night shifts interfere with the pituitary functions. As a result, the HGH plasma concentration will decrease.
♦ Different Modes of Administration
Although the accessible mode of HGH administration is by injection, there are alternative forms like pills and sprays.
Doctors and professionals recommend using the original injectable vials. However, some people find this method to be expensive. Besides, not everyone has a soft spot for painful daily needle pricks. HGH injection presents dramatic results, but it trails more adverse events than any other method of delivery.
However, when your preference is taking shots, you should settle on the subcutaneous option. The reason is that it is less painful with higher availability than the intra-muscular injection.
If you are easy-going, you can go for the pills. After all, this exogenous hormone is slow-acting, regardless of whether you are taking the injection or swallowing the tablets. One clear thing is that the side effects will be mild and perhaps tolerable. Besides, HGH price is friendly when you buy oral supplements.
♦ Accelerates the Recovery Process
Exogenous HGH speeds up the healing process of the muscular and the skeletal tissues. For this reason, doctors would recommend it as a therapy in case of severe burns or injuries.
In case of an injury, HGH work is to induce cell regeneration in the affected area. It facilitates the deposition of collagen on the wound, hence, shortening the recovery period.
♦ Accelerates Growth
Initially, researchers developed the recombinant growth hormone to manage short stature in youngsters. When the treatment is taken by teenagers, whose bodies are still growing, it will undoubtedly add a few inches to their height. Children receiving the treatment can gain up to 7” in less than five years.
HGH initiates growth in almost all tissues and organs, except the brain. For adolescents, the hormone promotes the development of bone and cartilages through replication of osteoblasts and chondrocytes. Moreover, it has a hand in inhibiting apoptosis or cell death.
♦ Enhances Performance
What makes HGH popular among bodybuilders is its ability to promote muscle strength and boost performance. Although some researchers do not buy into this reality, various findings have backed it up. In point of fact, why would the anti-doping agents ban HGH application in sports if it doesn’t have a hand in performance-enhancement?
For gymnasts, taking HGH will increase your stamina and endurance. At least you will put up with intense workouts and weightlifting. Besides, using the hormone will lengthen your exercise routine while improving your physical capacity since you’ll not quickly feel tired.
♦ A decrease in Bad Cholesterol
A high cholesterol level is the root cause of cardiovascular diseases. However, taking HGH reportedly lowers the scores, which is responsible for the development of arterial plaque.
♦ Boosts Metabolism
The human growth hormone indirectly affects metabolism by upregulating the insulin-like growth factor 1. Through the tyrosine kinase-mediated signaling pathway, IGF-1 activates the phosphorylation of various proteins on the peripheral cells. At the end, there will be an increase in metabolism and a decrease in catabolism.
The basal metabolic functions of the cells are proportional to the amino acid uptake and protein synthesis. What is more, the HGH work is to improve gluconeogenesis by promoting hyperglycemia.
♦ Corrects Erectile Dysfunction
HGH plays a significant role in reproductive health. Its deficiency leads to delayed puberty in children and a decrease in sexual functions among adults.
People suffering infertility are likely to have low levels of GH. Administering the hormone will help improve the production of testosterone, hence, stabilizing the sperm count.
♦ Clinical uses
HGH is an FDA-approved prescription drug for various conditions;
◦ Muscle wasting
◦ Short Stature
◦ Prader-Willi syndrome
◦ Renal failure
◦ Short bowel syndrome
◦ Turner syndrome
4. How Does HGH Work On the Human Body?
This exogenous hormone favors both males and females. Both genders register similar HGH results.
It is friendly to women for two reasons. The hormone is naturally synthesized in the human system. When research scientists employed the recombinant DNA technology in developing the synthetic form, they made sure its molecular composition was matching up with endogenous HGH. As a result, the body responds positively to its administration.
What’s more, this supplement is not a steroid. Yes, it is anabolic, but that is all.
▲ In Men
One thing that defines a man is his muscle strength. So, if your performance is deteriorating, HGH will gladly intervene. The hormone is a champ at giving you the stamina to engage in any physical activity. On the other hand, robust muscles and bones make you flexible while boosting your endurance, especially during intense training.
HGH works to improve your sex life. If you’ve got a history of infertility, erectile dysfunction, or low testosterone production, the hormone will step in to counter the effects. Moreover, it helps arouse sexual feelings while intensifying orgasm.
One more thing, the human growth hormone enhances the psychosocial being of a man. It pumps up most of the brain functions, including memory, thinking, cognition, and focus.
▲ In Women
Women care more about their appearance than any other thing. Therefore, it might not augur well with you if start noticing excess belly fat, sagging skin, wrinkles, dry skin, or thinning hairs. Note, I’ve deliberately ruled out gray hair from the list since it’s a sign of wisdom and most people find it magnificent.
HGH for women promotes cell regeneration and formation of collagen and elastin, which are responsible for youthful skin. In this case, the hormone works against sagging, aging spots, and wrinkles. As your muscles harden, so does your skin become firm and tight. Besides, you’ll no longer experience brittle hair as HGH thickens and strengthens individual shafts.
We all want that hourglass shape. However, GH-deficiency may lead to the deposit of fats around the abdominal or visceral area. Administering human growth hormone helps counter this effect by facilitating lipolysis.
If you care less about your body shape and appearance, you should take HGH for the sake of your cardiovascular health. Weight gain and excess fats around the belly are a root cause of heart disorders.
HGH for women also works to boost immunity and improve the sexual drive. Unlike anabolic steroids, HGH leaves no virilization effects. However, the dose should be as low as possible in women.
5. Human Growth Hormone (HGH) Use: Injection
The use of biosynthetic human growth hormone hinges on the goals you want to achieve. The dosage and the cycle vary depending on whether you’re using it as a bodybuilding supplement or as an anti-aging agent. Besides, the prescription for muscle wasting disorders will be different from that of short stature.
Take, for example; therapeutic doses can be so high compared to users who only want to enjoy the bodybuilding or HGH anti-aging benefits. However, physicians would employ short-term therapy that lasts for about four to six weeks.
5.1 HGH Injection vs. Other Modes of Administration
Injecting HGH has been the primary method of delivery before the introduction of oral pills and sublingual sprays. Injectable forms of this hormone have been dependable since they provide the best HGH results. Most people believe that they are the only valid supplements in the market.
If you want to get rid of excess abdominal fats, inject HGH precisely in that area. Consistently injecting the hormone on a particular site accelerates localized fat loss.
You can administer HGH injection either intramuscularly or subcutaneously. Of these two, bioavailability is higher in the latter than the former. The HGH half-lives in intramuscular and subcutaneous injections are 3.4 and 0.36 hours, respectively.
The best time to inject HGH is after the last meal when you’re about to sleep. You can administer in the abdominal area, stomach, thighs, or deltoid. Keep shifting the sites to avoid bruising or recurring pain.
The major drawback of injectable forms of HGH is that they are too painful to endure, especially by children and teenagers. Considering that you have to inject the drug daily, some people would intentionally miss their doses due to trypanophobia.
5.2 HGH Cycle: With or Without Anabolic Steroid?
The best thing about HGH is that you can use it as a standalone bodybuilding supplement or stack it up with other anabolic steroids. The reason why people club it with other supplements in their cutting and bulking cycle is to amplify the results while trimming down the side effects.
If you are neither an active athlete nor a competitive bodybuilder, there might be no need for pairing HGH with an anabolic steroid. In this case, you can take the minimal dose of about 2IU for 12 to 16 weeks.
5.3 HGH Cycle Guide
If your goal is to enhance performance, the typical daily dosage is between 2IU and 8IU. For instance, when you are taking HGH in a stacking cycle, the dose should be as low as 2IU to 4IU. This supplement is among the few performance-enhancing drugs, which can be comfortably used by females. However, HGH for women requires that you halve the dosage of what a man takes.
The HGH treatment can run up to 16 weeks. If you prolong the cycle, there’s a likelihood of suffering the side effects. Those taking a maximum of 2IU per day may choose to go slightly beyond the 16-week-phase. However, people using more than 4IU should stick to this time interval lest they end up suffering from acromegaly.
To start your cycle, consider administering single injections at the dosage of 2IU within the first four weeks. Subsequently, you can increase the daily measure and split it into two separate doses. Ideally, end the cycle at the twelfth-week and give yourself a two to four-week recovery period before beginning the next cycle.
|Goal||Daily Dosage (Men)||Daily Dosage (Women)|
|Therapeutic applications||8IU – 16IU||6IU – 12IU|
|Muscle mass||4IU – 8IU||2IU – 4IU|
|Performance||2IU – 4IU||1IU – 2IU|
|Anti-aging||1IU – 2IU||0.5IU – 1IU|
During the HGH cycle, you should keep an eye on any physiological changes on your body. Although rare, some people would experience high blood pressure. However, this effect is prevalent among users taking high doses. In case your BP shoots up, make sure to lower the dose.
Additionally, you should check out the signs of acromegaly. Once your glove no longer fits or your shoe has become abnormally small for your foot, break off from the hormone. These symptoms are a red light of how alarming your heart is enlarging.
5.4 The HGH Stacking
In the cutting phase, your stacking options include, but not limited to, Anavar and Primobolan. If you are already dieting and exercising regularly, ensure to shorten the HGH cycle to a maximum of 10 weeks. Prolonging the phase will make you lose a lot of calories to other health risks.
For bulking, you can pair it up with either Trenbolone Enanthate or Deca Durabolin. Other classic stacks incorporate testosterone and Sustanon-250.
The significance of clubbing this hormone on your cycle is that it is versatile. At least, the HGH benefits will linger while steroid side effects will be mild and less severe. In a stack, make sure to use low doses of the human growth hormone.
5.5 HGH for Post Cycle Therapy
Before a typical steroid cycle ends, ensure to administer a minimum dose within the last four weeks. In doing so, the level of growth hormones in the body will be downregulated to befit the recovery period.
Incorporating HGH for weight loss in your PCT preserves your gains while putting a stop to possible water retention, which occurs after completing treatment. However, if you want to enjoy the anabolic benefits of this exogenous hormone, make sure that your cycle lasts between eight and twelve weeks.
For better results, you can combine HGH with other anti-estrogen treatments like Nolvadex and Clomid.
6. HGH Results: Before And After
The HGH results do not suddenly pop up overnight. Although it acts at a snail’s pace, a dramatic outcome is a guarantee. The earliest you will start registering changes is after the first month of administration. However, excellent results come knocking at the end of six months.
During your cycle, you should not only anticipate the results but also keep track of your physiological progress. Take, for example, documenting the effects of HGH before and after the taking the injection will alert you if at all you develop negative upshots.
To back up the efficiency of the human growth hormone, I’ll walk you through some of the successful clinical case studies. According to a 1996 study, researchers found out that HGH enhances recovery in men aged above 69 years. The subjects taking this hormone had an increase in collagen deposition compared to the placebo.
Rudman and his colleagues set out to investigate the effect of HGH on men between 61 and 81 years on a six-month administration. At the conclusion, he discovered that there was an increase in lean muscles by 8.8%, 1.6% bone density, and a 14.4% decrease in fats. This research was a groundbreaking discovery, which saw the use of HGH as an anti-aging agent.
A study targeting 24 obese victims aged between 22 and 46 years had its subjects enjoy over three HGH benefits on a single 12-week cycle. The treatment led to a decrease in visceral fat, an increase in lean body mass, positive nitrogen balance, and production of IGF-1. The conclusion is based on the fact that HGH before and after administration has some anabolic effects on the human body.
Ways to Improve the HGH Results
▪ Get Enough Sleep
High levels of HGH are released when you are deep asleep. Therefore, try going to bed early and sleep for at least seven to eight hours. If you are doing the night shifts, ensure to make up for the disrupted circadian cycle.
At twilight, develop positive habits that will optimize your sleep. For example, before retiring to bed, you can avoid blue light exposure by reading a book. Also, desist from consuming caffeine after sunset.
▪ Check Your Diet
You should limit a high intake of sugar or carbohydrates. These two nutrients raise the insulin level and facilitate weight gain. Steer clear from calories and consume healthy fats. If you have a sweet tooth, make an effort to work on it.
▪ Exercise Regularly
Intense training helps improve the production of human growth hormone. Ensure that the workout intensity is beyond the lactate threshold. Exercising while taking synthetic HGH supplements will accelerate weight loss, muscle strength, and the well-being of a person.
▪ Embrace Liver Detox
During the indirect mechanism of action, HGH induces the synthesis of IGF-1 by the hepatocytes. However, this physiological operation may never happen if you have liver disease. Detoxifying this organ improves the working of HGH and IGF-1 by reversing poor liver functions and the related disorders.
7. What Happens If You Have Too Much Or Little Growth Hormone?
The hypothalamus is in control of HGH regulation. This part of the brain triggers the release of growth hormone-releasing hormone (GHRH) and the growth hormone-inhibiting hormone (GHIH). These two peptides are otherwise known as somatocrinin and somatostatin, respectively.
In situations where GHRH and GHIH cannot balance in the human body, a person will end up either with excess or too little growth hormone.
7.1 Too Much Growth Hormone (GH)
Excess GH occurs in different ways. The most common abnormality happens when a tumor, consisting of somatotrophic cells, forms in the anterior pituitary. Although the swelling grows at a snail’s pace, the development is progressive, leading to more and more atypical production of HGH.
GH-secreting adenomas seldom occur in childhood. Once in a blue moon, youngsters with excess HGH will encounter pituitary gigantism or excessive growth. However, the tumors will usually affect adults in their 50s or older, leading to acromegaly.
Between 19 to 21 years, growing comes to a halt as the epiphyseal growth plates close up. When there is excess HGH in the circulation, abnormal bone growth will ensue. The affected organs include the skull, feet, hands, jaws, and the sternum. The realization that your shoe, hat, mask, or gloves are no longer fitting, should be a caveat.
The difference between gigantism and acromegaly is that the former occurs in childhood before the closure of the epiphyses. Conversely, acromegaly is prevalent in adulthood.
Sings and Effects of GH Hypersecretion
◦ Impaired vision due to too much pressure impacted on the optic nerves
◦ Too much fat around the belly
◦ Increase in bad cholesterol
◦ Massive jaws as a result of thickened bones
◦ Displacement and decline in other pituitary hormones
◦ Too much sex hormone-binding globulin (SHBG)
◦ Muscle weakness
◦ Carpal tunnel syndrome
◦ Insulin resistance
◦ Myocardial enlargement
◦ Certain Cancers
There are up to three different ways of managing HGH-secreting adenomas. The most widely held method is surgical removal of the swelling. Besides, radiation therapy can be used to suppress the tumor. In some cases, physicians prescribe somatostatin antagonists, which take effect by blocking the production of growth hormones.
7.2 Too Little Growth Hormone (GH)
This abnormality is prevalent in childhood. The etiology can be congenital as a result of hypothalamic damage or the pituitary gland injury. In a few cases, GH-deficiency is due to mutations in the genes responsible for secretion and synthesis of HGH.
The decline in the production of HGH is majorly dependent on the Insulin-like Growth Factor-1 (IGF-1). For instance, when the liver fails to produce IGF-1, the hormonal level will fall off. What is more, the body tissues can be unresponsive to IGF-1. All these factors lead to a decline in the Human Growth Hormone.
In adults, pituitary adenomas are the root cause of GH-deficiency. Other causes may include surgery, radiotherapies, head injury, or meningitis. It is so hard to diagnose the deficit of the human growth hormone in adulthood. Although there are symptoms related to it, most people will rule out the effects as common to old age.
Signs and Effects of HGH-deficiency
In children, too little HGH leads to the following;
◦ Short Stature
◦ Impaired hair growth
◦ Prominent head
◦ Growth failure
◦ Delay in puberty or secondary sexual characteristics
◦ Among adults, the following may occur;
◦ Dry skin
◦ A decrease in muscle strength
◦ Increased adipose tissue
◦ Weak bones, which cause osteoporosis
◦ Increase in fat mass
◦ Anxiety and depression
◦ Cardiovascular dysfunction due to insulin resistance or dyslipidemia
◦ Reduced cognitive functions
Patients with HGH-deficiency are treated with synthetic human growth hormone. At least, they are the only group of people who can access and legally walk around with the hormone as though it’s a pair of sneakers.
8. HGH Side Effects: Is There Any Risk With HGH Injection?
HGH side effects hinge on the dosage amount and the mode of drug administration. For example, taking high doses and long cycles will magnify the negative upshots. However, this factor is not so applicable when the drug is treating muscle wasting, short stature, or GH-deficiency. Studies show that even though the therapeutic doses are extreme, the side effects will be rare.
Let’s delve into the HGH side effects;
▪ Fluid Retention
▪ HGH flu that will likely die out over time
▪ Pain along the joints, muscles, and the bone
▪ High risk of diabetes
▪ Swollen joints, hands, legs, feet, and arms
▪ Carpal tunnel syndrome
▪ Hodgkin’s lymphoma
▪ Reduced insulin sensitivity
▪ Increase in blood sugar levels
Even on responsible HGH use, the user is still likely to experience most of the above symptoms. However, this risk increases with an increase in the dosage. Some effects, such as Type II diabetes, pains, and swellings, would fade away once you discontinue the treatment.
For hypothyroidism, you can manage it using Cytomel (T3). For hygienic purposes, make sure to use sterilized syringes during injections.
Unless a physician prescribes the drug, do not take it when you already have an underlying medical condition. HGH for weight loss is only meant for healthy users.
If you fall in the list below, make sure to avoid the biosynthetic HGH like the plague.
▪ Cancer patients.
This group includes anyone that has ever had cancer or is at risk of developing the disease. Researchers suggest that HGH may accelerate the growth of certain types of malignant tumors.
HGH is likely to interfere with the physiological mechanism of insulin response.
▪ Heart conditions
Some studies indicate a high probability of heart enlargement on users taking the drug.
▪ Patients with carpal tunnel syndrome
The human growth hormone may worsen this condition, as it directly affects the ligaments, tendons, and the joints.
HGH elevates the blood pressure.
9. 2019 Best-Selling Human Growth Hormone on Sale
There are two sure ways of acquiring the biosynthetic human growth hormone. You either walk around with a doctor’s prescription or effortlessly buy HGH from an online store. Although some street vendors are peddling it, buying from them should be the least option as it can be a death trap.
HGH for sale is illegal in the U.S. unless a doctor prescribes it. However, countless online sellers are dealing with the manufacture and distribution of the hormone.
To pass up scams and fake products, you ought to bank on a genuine HGH supplier, which gives a detailed description of the compound. You should then find out more about the seller and any check out for any product reviews from the users.
Here are some of the best-selling HGH in the market;
This product is not famous for nothing. In the real sense, it is currently the premium HGH for sale.
HGH-X2 boosts muscle growth, enhances metabolism, and improves the performance of the user. Moreover, you can take it if your goal is to lose extra fat or increasing sex drive. Just like the endogenous HGH, this supplement induces cell regeneration, which is essential for positive development.
HGH-X2 is available in pill form. Taking it will only boost and stir up the release of the human growth hormone. You can take two capsules daily for the next 15 days or do a three-dose routine for ten days.
The key ingredients making up HGH-X2 include Maca, Hawthorn Berry, L-Arginine, and Velvet Beans.
This product contains all the essential amino acids that stimulate the release of HGH. Each of its ingredients has a role to play in reversing aging, building muscles, enhancing performance, or speeding up metabolism.
For example, L-Arginine, which has the highest measurement per serving, is beneficial for maintaining robust but lean muscles. On the other hand, L-Glutamine and L-Tyrosine improve cognition and regulate metabolism, respectively.
Other amino acids present in GenF20 include L-valine, L-Glycine, L-Ornithine, and L-Lysine. In a single serving, you won’t miss a taste of Deer Antler Velvet, Astragalus Root Extract, GABA, phosphatidylcholine, colostrum, and GTF chromium.
GenF20 users confess that they start seeing results after a month of administering the supplement. A summary of the customers’ reviews revolves around flawless skin, diminished wrinkles, fewer age spots, high stamina, and better sleep.
This supplement is among the oldest HGH for sale in the market. If you can’t put up with daily painful injections and its side effects, you need to try GenFX.
Its primary function is to boost the production of endogenous growth hormone. Therefore, it will indirectly lead to cellular regeneration. At the same time, GenFX slows down the aging process by tightening your skin so that there is neither sagging nor wrinkling.
This product richly contains up to 12 amino acids. A single bottle contains 30 tablets on a dose of two capsules a day. Being a natural supplement, GenFX exhibits no adverse HGH side effects.
9.1 Blood Testing: How Do You Know Whether Your HGH Is The Best?
Real human growth hormone should contain the same molecular composition as that of the natural HGH produced in the pituitary gland. However, you can never test the legitimacy of a product by looking at it. Moreover, you will still not judge by the results considering that anabolic agents will always exhibit almost similar characteristics.
If you come across an HGH supplier with pharmaceutical-grade supplements, you have fallen for the crème. In this case, the drug should be in injectable rather than in pill or spray forms.
Some HGH test-kits can identify genuine products from counterfeits. The kit utilizes the respective antibodies of the human growth hormone to detect somatropin. If you buy HGH with fake GHRP peptides, the test-kit will still let you know. The costs of this HGH testing equipment rarely go beyond the 100 dollar mark.
Blood serum testing is a sure method of detecting the presence of HGH in the body. At least, it can distinguish between the synthetic and endogenous growth hormone in the human system. High levels of HGH in the blood are not a reliable way of ruling out the likelihood of doping.
There are two distinct analytical methods for HGH detection in the blood;
♣ Isoform Differential Immunoassays
The isoform approach was first applicable at the 2004 Olympics as a research-test. It is currently the major HGH blood test running in all the WADA-accredited labs.
Once you inject yourself with this artificial hormone, some detectable changes will occur in the various isoforms of endogenous HGH. The Differential Immunoassay Approach checks for alterations on the proportions of the natural human growth hormone in the blood, before ruling out the presence of foreign HGH.
♣ The Biomarkers Test
The biomarkers approach is barely a decade old. It was first introduced as an HGH testing technique during the 2012 Olympic Games in London.
Here, the test measures the increase in IGF-1 and the N-terminal peptide (P-III-NP). These two are biomarkers of HGH.
9.2 Human Growth Hormone Price Online
This supplement is among the few expensive anabolic agents in the bodybuilding industry. HGH price majorly depends on whether the dosage is injectable or orally taken. For example, a full oral dose will go for about $200 and $300.
If you care about results, you might consider the HGH injection. In this case, I bet you will have to break the bank. A single dose will sell for about $20. If you have to inject HGH twice a day for a week, the value will roughly add up to $280. In a month, you will be shelling out over $1000 on the growth hormone. At the end of a 12-week HGH cycle, you will have coughed up close to $5000.
Studies prove that there is a wide range of HGH application. Whether you want to lose a few pounds, gain some lean body mass, or gain maximum muscle strength, HGH will do it.
Although some scientists maintain that the hormone has no anabolic effects, several clinical studies prove otherwise. Due to this controversy, you’re left to wonder why anti-doping agencies would ban HGH use in sports, yet it does not enhance the athletic performance. Do people want us to believe that taking this treatment is more like gulping a glass of juice?
The most significant advantage of using HGH is that the results are there to stay. The only things that die out are the side effects. So, if you want to watch the belly fat disappear together with sagging skin and wrinkles, buy HGH and incorporate it into your regimen.
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Papadakis, M.A., Hamon, G., Stotts, N., Spencer, M.E., et al. (1996). Effect of Growth Hormone Replacement on Wound Healing in Healthy Older Men.
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