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Adrafinil Vs Modafinil, Which One Is Suitable For You

Adrafinil Vs Modafinil, Which One Is Suitable For You?

  3. Is Adrafinil a Stimulant?

Both Adrafinil and Modafinil are stimulant nootropics for enhancing cognitive functions. These two eugeroics boost brainpower and promote wakefulness. Therefore, they can be the prime choice when you are too sleepy, yet you’ve got to work through your night shift.

Caffeine, amphetamines, and the related stimulants would always target the entire nervous system and the overall physiological activities. However, adrafinil and modafinil will zoom in on the brain chemical organs.

The action of nootropics on the brain is often long-lasting. They boost alertness without igniting critical withdrawal effects such as euphoria, agitation, or exhaustion. The drugs are no doubt excellent recommendation for narcolepsy and the related sleep disorders.

So, what is the hype about adrafinil vs modafinil? Let’s find out.

History of Adrafinil vs Modafinil  aasraw

Adrafinil was first discovered in France in 1974 by the Lafon Pharmaceuticals the discovery was by a quirk of fate since the scholars were working to invent analgesics. This company teamed up with the famous sleep researcher, Michel Jouvet, to test the role of this compound in sleep psychology and neurological health.

In 1984, Lafon Pharmaceuticals officially released adrafinil in the French market. The drug was later clinically prescribed as a narcoleptic treatment in 1985. Four years later, the substance was all the rage in the US and the entire globe.

In 1976, Lafon adrafinil psychonauts discovered that there was an active ingredient, which was solely responsible for the adrafinil effects. The scholars established that it was the compound’s metabolite. Adrafinil is a prodrug, which has to be first activated by the liver into modafinil.

Lafon researchers set out on a mission to isolate the active metabolite. After successful isolation, the group came up with modafinil drug. The compound was more potent, and it delivered rapid results than its precursor. By 1994, the French authorities had legalized it.

In 1998, modafinil won the FDA endorsement as a narcoleptic drug. Five years later, the medication was indicated for patients with daytime hypersomnia, which relates to obstructive sleep apnea and individuals with shift-work sleep disorders.

In 2001, Cephalon Inc., an American-based pharmaceutical company, bought Laboratoire Lafon for $450 million. A decade later, this company brought to a halt the production of adrafinil as FDA had revoked their license.

Raw adrafinil is a compound with CAS number 63547-13-7 while modafinil is represented by 68693-11-8.

Brand Name of Adrafinil vs Modafinil  aasraw

Laboratoire Lafon initially sold adrafinil powder under the brand name, Olmifon.

Modafinil is marketed as Provigil®. Other generics trade names include;

  • Modalert
  • Alertec
  • Wakelert
  • Alertex
  • Vigimax
  • Mentix
  • Zalux
  • Forcilin
  • Modasomil
  • Modafinilo
  • Vigicer
  • Aspendos
  • Movigil
  • Vigil
  • Modanil
  • Modvigil
  • Modaheal
  • Modiodal
  • Altasomil
  • Intensit

Is Adrafinil a Stimulant?  aasraw

Yes! Adrafinil is a stimulant. This aspect is probably the reason why anti-doping agencies forbade it in sports. The smart drug stimulates the central nervous system in two ways. Firstly, it relieves sleepiness. Secondly, it improves alertness.

Unlike other stimulants which stir up the motor coordination, adrafinil is solely a cerebral stimulant. Therefore, the drug will neither cause a jittery feeling nor hyperactivity.

Adrafinil Vs Modafinil, Which One Is Suitable For You

Adrafinil vs Modafinil: What are The Similarities?  aasraw

Both adrafinil and modafinil work the same way. Therefore, the two nootropics exhibit similar effects and benefits. Upon ingestion, metabolism takes place in the liver. Adrafinil converts into modafinil as an active metabolite.

Mechanisms of Action

The two nootropics target the hypothalamic and amygdala neurons, which upregulate the production of the brain’s hypocretin. Adrafinil and modafinil bump up the levels of histamine and norepinephrine. These actions not only trigger off alertness and maximum concentration but also wakefulness.

Besides, the stimulated neurons increase the availability of glutamate. This neurotransmitter enhances memory and the boosts up the general cognitive functions.

Adrafinil and modafinil also work to increase dopamine levels in the brain. Traditional stimulants will only trigger off the release of dopamine. However, taking eugeroics will stand in the way of neural receptors, which are liable for flushing out this key neurotransmitter. The dopaminergic system sparks alertness and elevates the mental state.

Effects and Benefits

Although these two smart drugs are exceptionally efficient for improving brain functions, modafinil is more potent than adrafinil.

These eugeroics were purposely invented for treating narcolepsy and managing shallow/irregular breathing during sleep. However, numerous studies and clinical trials support that the drugs promote fluid intelligence and boost up the mood. Besides, they exhibit neuroprotective properties, hence, playing a significant role in the overall brain health.

Adrafinil and modafinil are wakefulness-promoting agents. If you are a student with a critical exam ahead, you can use the drugs as a sure bet of burning the midnight oil. They alleviate fatigue, tiredness, and drowsiness by boosting alertness.

Adrafinil effects may run up to 15 hours before wearing off. Some French pilots take it as a counteracting measure in case of an emergency. Besides, army officers, drivers, and machine operators use smart pills to help them stay alert and endure sleep deprivation. In France, the US, and the UK, the military personnel legal take modafinil as a substitute for amphetamines, especially when undertaking long missions.

Although the cognitive enhancers will hold back the urge to sleep; you’ll never experience extreme rebound sleepiness that’s typical with other stimulants.

When it comes to brain functions, these two eugeroics are a champ at improving the cognitive abilities. For instance, they enhance the working memory and the mental performance of the user, especially in situations that call for critical thinking.

Adrafinil and modafinil trigger the increase in histamines, dopamine, and norepinephrine. The three neurotransmitters lead to an increase in the physical energy levels. Thus, the drugs are a spot-on supplement for active athletes undertaking intense workouts. Note that these two nootropics are stringently prohibited in competitive sports.

A skim through adrafinil amazon reviews confirms that the smart pill can effectively manage ADHD, chronic fatigue syndrome, and depression. Besides, some recent studies speculate that modafinil powder helps cocaine addicts to fight drug dependence.

Adrafinil vs Modafinil: What Are The Differences? aasraw

It’s not easy to establish the difference between these two since the results are one and the same. However, you should note that adrafinil is a prodrug. It is an inactive ingredient, which has to pass through the liver for metabolism before it can provide neurological benefits.


Modafinil has a higher potency than adrafinil. Therefore, you’ll require to double adrafinil dosage if you’re looking for exceptional results. Not all of this smart drug will fully convert into modafinil as it undergoes metabolism into the liver. For this reason, you will have to make up for the inactivated form by taking adrafinil high doses.

A typical daily modafinil dosage ranges between 100mg and 200mg. However, some people would do up to 400mg in a single day.

For adrafinil, the average dosage is between 300mg and 600mg. Some valiant users would extend the dose to 1200mg. For a novice, it’s ideal to use low quantities of the drug until you are sure that your body can tolerate a high amount.

The amount partly hinges on your body weight. For example, physicians and healthcare providers recommend 10mg of the drug per kilogram. In this case, if you weigh 90kg, you’ll need to use 900mg of adrafinil.

These cognitive enhancers are available in powder, capsule, or tablet form. Since they have a high solubility, you can take them with water or juice, preferably on an empty stomach. Fatty meals could interfere with the mechanism of action. In case you’re treating narcolepsy or a related sleep disorder, you ought to follow the doctor’s instructions.

Adrafinil and modafinil effects may last between 12 and 15 hours. Therefore, you should take the supplement early in the morning so as not to interfere with your usual sleep cycle.

However, if you’re wild about the nootropic benefits, then you should use them occasionally. For instance, take adrafinil only when working extra hours to beat stringent deadlines or doing a nightshift.


Let’s compare adrafinil vs modafinil. So, which one is more toxic than the other? Allow me to break it down for you.

Adrafinil has a first pass metabolism through the liver as it converts into modafinil. As a result, the drug might overwhelm this organ, leading to hepatoxicity. In some cases, this nootropic is responsible for the increase in liver enzymes.

Well, do not make a fuss since liver toxicity is quite rare. If you only administer adrafinil powder for a short-term duration, you’ll not fall prey of this negative upshot.

Onset time

Before it acts on the neurological system, adrafinil has to be sorted out on the liver. Therefore, the action of the drug on the body can be sluggish. This smart drug will max out into the circulation within three to five hours.

Modafinil acts rapidly, as it does not require metabolism or conversion. It will take between 60 and 90 minutes for this nootropic to reach peak levels.


Modafinil has a half-life of about 14 hours. Contrary, adrafinil lingers on the human system for an hour or two before being converted into an active ingredient. Its half-life is about 15 to 16 hours.


For adrafinil and modafinil, the only guaranteed way to tell them apart is by puzzling out their potency. However, what indelibly separates them is their legitimacy.

Unlike modafinil, adrafinil is unregulated in most states. You won’t need a valid prescription to obtain it. Acquiring this smart drug is as easy as splashing out on a pair of sneakers.

Contrary, modafinil powder is a controlled substance in the US, some European states, Canada, China, Japan, and Australia. You will need a valid prescription from a certified physician for you to acquire the drug. Other countries such as Mexico, the UK, Finland, and Sweden have not listed modafinil as a controlled substance, but a prescription is still necessary.

The use of either adrafinil or modafinil is illegal in the sports arena. From 2004, the World Anti-Doping Agency has since proscribed its use in or out of the competitive athletics.


Modafinil is incredibly expensive. However, the costs hinge on the seller. The price of adrafinil is a fraction of that of modafinil.

Speaking of costs, I’m probably leaving you wondering where to buy adrafinil, right? If you are looking for an absolute deal, check in with us and relish our discounted rates.

Side effects

Both adrafinil and modafinil present similar side effects. However, the former can be very toxic to the liver, especially on long-term usage.

Typical adrafinil and modafinil side effects include headaches, blood pressure, change in heart rhythms, and gastrointestinal distress. Taking adrafinil high doses may potentially decrease the frequency of urine. Besides, prolonged dosages will likely trigger off epilepsy and kidney failure.

A quick check on the adrafinil reviews confirms that the supplement also suppresses appetite. Most users report that they rarely feel hungry while on the drug. This effect can be a blessing in disguise, especially to individuals who want to shed off some extra body weight.

In case you don’t take adrafinil on time, the chances are you’ll likely struggle with insomnia. Since the wakefulness period stretches up to 15 hours, you’re required to wake up extra early to take the drug. Failure to follow this schedule will have you suffer the consequences of staying up late.

Adrafinil Vs Modafinil, Which One Is Suitable For You

Adrafinil vs Modafinil: Which One is Suitable for You?  aasraw

The most suitable smart pill depends on your situation, what you’re looking for in the nootropic agent, and your lifestyle. Each drug has its shortcoming. Take, for example, adrafinil powder is legal in most states, but it has a long half-life and is likely to overwhelm the liver. On the other hand, acquiring modafinil needs a valid prescription. However, the drug acts rapidly and is quite potent.

Modafinil is quite potent, and it will deliver the results within no time. Besides, it has no toxic implications on the liver. However, you should only take it when your doctor has prescribed it.

The notable advantage of modafinil is its short half-life. Therefore, scheduling the doses is as easy as the count of three. In doing so, you’re less likely to interfere with your regular sleep patterns or the circadian rhythm.

If you check through adrafinil wiki content, you’ll realize that it’s undeniably the most exceptional choice for every other user. Let me explain. This smart drug is unregulated in several countries. As a result, most authorities will not give a hoot whether you’ve purchased it with or without a prescription. So, if you aim for the nootropic benefits of nootropics rather than managing a sleep disorder, adrafinil is the way to go.

The drug is also cost-effective. You don’t need to break the bank, and you might not even require insurance to cover part of the costs.

Adrafinil Vs Modafinil Conclusion  aasraw

Both adrafinil and modafinil are safe, tolerable, and efficient to the users. Although they seem identical, modafinil is ideal if your doctor recommends it.

However, if you wish to take advantage of the nootropic benefits of eugeroics, adrafinil is the prime alternative. It is legally available in default of a prescription and is also obtainable as a dietary supplement. While the adrafinil reviews are comparatively positive, you should be cautious about the drug’s legality and the side effects.

Whether you’re working the graveyard shift or staying up late in the office due to voluminous assignments, adrafinil will transform you into a night owl. If you’re studying for a test, the smart drug will not only improve your intellectual capacity but also boost your memory.

To bypass the adrafinil side effects, make sure to take the drug for short-term periods. In a week, you ought not to exceed three days.



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  2. Ballas, C.A., Kim, D., Baldassano, C.F., and Hoeh, N. (2002). Modafinil: Past, Present, and Future.Expert Review of Neurotherapeutics.
  3. Mereu, M., Bonci, A., Newman, A.H., and Tanda, G. (2013). The Neurobiology of Modafinil as an Enhancer of Cognitive Performance and a Potential Treatment for Substance Use Disorders.
  4. Dongsoo Kim. (2012). Practical Use and Risk of Modafinil, a Novel Waking Drug. Environmental Health and Toxicology.
  5. Siwak, C.K., Callahan, H., and Milgram, N.W. (2000). Adrafinil: Effects on Behavior and Cognition in Aged Canines.

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